Primary Care Diabetes
Volume 1, Issue 3 , Pages 173-175, September 2007

Problem of using hemoglobin A1C measurement in endemic area of hemoglobinopathy

Department of Clinical Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

Received 23 January 2007; received in revised form 15 June 2007; accepted 9 July 2007.

Abstract 

Diabetes mellitus (DM) is a frequent disorder affecting individuals of all ages. Glycohemoglobin (GHb) has a key role in the assessment of glycemic control in diabetic patients. Generally, GHb is measured as hemoglobin (Hb) A1C and is the result of an irreversible non-enzymatic glycation of the beta chain of hemoglobin A. HbA1C is used routinely to assess long term glycemic control in patients with DM. A variety of patient- and laboratory-related factors can adversely affect the measurement of HbA1C in patients harboring Hb variants or derivatives. In this article, problem of using hemoglobin A1C measurement in endemic area of hemoglobinopathy is addressed.

Keywords: Hemoglobin A1C, Hemoglobinopathy, Laboratory

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PII: S1751-9918(07)00075-7

doi:10.1016/j.pcd.2007.07.004

Primary Care Diabetes
Volume 1, Issue 3 , Pages 173-175, September 2007

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