Primary Care Diabetes
Volume 2, Issue 1 , Pages 45-49, 2008

Lowering HbA1c in type 2 diabetics results in reduced risk of coronary heart disease and all-cause mortality

  • Rien ten Brinke

      Affiliations

    • All authors contributed equally to this article.
    • ,
  • Nicky Dekker

      Affiliations

    • All authors contributed equally to this article.
    • ,
  • Marjolein de Groot

      Affiliations

    • All authors contributed equally to this article.
    • ,
  • David Ikkersheim

      Affiliations

    • All authors contributed equally to this article.
    • Corresponding Author InformationCorresponding author. Tel.: +31 6 41 83 96 26.

University Medical Center Utrecht (UMCU), Van Brakelstraat 9 bis, 3572 XP Utrecht, The Netherlands

Received 17 December 2007; accepted 18 December 2007. published online 13 February 2008.

Abstract 

Aims

To assess to which extent lowering the level of HbA1c influences the 10-year risk of coronary heart disease (CHD) and all-cause mortality in patients with type 2 diabetes mellitus.

Methods

A literature search in Pubmed and Embase was performed, and the absolute risks in the results of the relevant and valid studies compared.

Results

Each study shows that with a decreasing percentage of HbA1c, both the risk of developing CHD and the risk of mortality decrease.

Conclusions

Lowering HbA1c in type 2 diabetics decreases the absolute risk of developing CHD by 5–17%, as well as decreasing all-cause mortality by 6–15%.

Keywords: Diabetes mellitus type 2, HbA1c, Coronary heart disease, Mortality

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PII: S1751-9918(07)00184-2

doi:10.1016/j.pcd.2007.12.004

Primary Care Diabetes
Volume 2, Issue 1 , Pages 45-49, 2008

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