Primary Care Diabetes
Volume 2, Issue 2 , Pages 65-66 , June 2008

Preventing type 2 diabetes: Genes or lifestyle?

  • Mary Beth Weber

      Affiliations

    • Corresponding Author InformationCorresponding author at: Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA. Tel.: +1 404 727 6949; fax: +1 404 727 3350.

Received 10 March 2008

References 

  1. The World Health Organization, Country and Regional Data: Prevalence of Diabetes Worldwide. http://www.who.int/diabetes/facts/world_figures/en/.
  2. O’Rahilly S, Barroso I, Wareham NJ. Genetic factors in type 2 diabetes: the end of the beginning?. Science. 2005;307:370–373
  3. Narayan KM, Zhang P, Kanaya AM, et al. Diabetes: the pandemic and potential solutions. In:  Jamison DT,  Breman JG,  Measham AR, et al. editor. Disease Control Priorities in Developing Countries. New York: Oxford Investment Press; 2006;p. 591–604(Chapter 30)
  4. Knowler WC, Narayan KM, Hanson RL, et al. Preventing non-insulin-dependent diabetes. Diabetes. 1995;44:483–488
  5. Florez JC, Jablonski KA, Bayley N, et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N. Engl. J. Med. 2006;355:241–250
  6. Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance—a population-based twin study. Diabetologia. 1999;42:139–145
  7. Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007;316:1341–1345
  8. Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007;316:1336–1341
  9. Jafar-Mohammadi B, McCarthy MI. Genetics of type 2 diabetes mellitus and obesity—a review. Ann. Med. 2007;1–9
  10. Weedon MN. The importance of TCF7L2. Diabetes Med. 2007;24:1062–1066
  11. Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007;316:1331–1336
  12. Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet. 2006;38:320–323
  13. Weedon MN, McCarthy MI, Hitman G, et al. Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med. 2006;3:e374
  14. Ramachandran A, Snehalatha C, Mary S, et al. The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia. 2006;49:289–297
  15. Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20:537–544
  16. Lindstrom J, Louheranta A, Mannelin M, et al. The Finnish Diabetes Prevention Study (DPS): lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care. 2003;26:3230–3236
  17. Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 2002;346:393–403
  18. Eriksson KF, Lindgarde F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. The 6-year Malmo feasibility study. Diabetologia. 1991;34:891–898
  19. Lindstrom J, Ilanne-Parikka P, Peltonen M, et al. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet. 2006;368:1673–1679
  20. Pearson ER, Donnelly L, Doney AS, et al. Pharmacogenetics in type 2 diabetes: variation in TCF7L2 influences response to sulphonylureas. Diabetic Med. 2007;24:5

PII: S1751-9918(08)00034-X

doi: 10.1016/j.pcd.2008.03.005

Primary Care Diabetes
Volume 2, Issue 2 , Pages 65-66 , June 2008

Article Tools