Primary Care Diabetes
Volume 2, Issue 4 , Pages 207-211 , December 2008

Easily obtainable clinical features increase the diagnostic accuracy for latent autoimmune diabetes in adults: An evidence-based report

  • Maurice W.M.D. Lutgens

      Affiliations

    • University Medical Center Utrecht, Faculty of Medicine, The Netherlands
    • All authors contributed equally to this manuscript.
    • ,
  • Melanie Meijer

      Affiliations

    • University Medical Center Utrecht, Faculty of Medicine, The Netherlands
    • All authors contributed equally to this manuscript.
    • ,
  • Babette Peeters

      Affiliations

    • University Medical Center Utrecht, Faculty of Medicine, The Netherlands
    • All authors contributed equally to this manuscript.
    • ,
  • Marie-Louise N.F. Poulsen

      Affiliations

    • University Medical Center Utrecht, Faculty of Medicine, The Netherlands
    • All authors contributed equally to this manuscript.
    • ,
  • Marjet J. Rutten

      Affiliations

    • University Medical Center Utrecht, Faculty of Medicine, The Netherlands
    • All authors contributed equally to this manuscript.
    • ,
  • Michiel L. Bots

      Affiliations

    • Julius Center for Health Sciences and Primary Care, UMC Utrecht, The Netherlands
    • All authors contributed equally to this manuscript.
    • ,
  • Geert J.M.G. van der Heijden

      Affiliations

    • Julius Center for Health Sciences and Primary Care, UMC Utrecht, The Netherlands
    • All authors contributed equally to this manuscript.
    • ,
  • Sabita S. Soedamah-Muthu

      Affiliations

    • Julius Center for Health Sciences and Primary Care, UMC Utrecht, The Netherlands
    • All authors contributed equally to this manuscript.
    • Corresponding Author InformationCorresponding author at: University Medical Centre Utrecht, Julius Center for Health Sciences and Primary Care, Huispostnr str.6.131, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. Tel.: +31 88 75 59379; fax: +31 88 75 55485.

Received 15 October 2007 ,Revised 13 January 2008 ,Accepted 13 August 2008.

References 

  1. Verge CF, Stenger D, Bonifacio E, Colman PG, Pilcher C, Bingley PJ, et al. Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: combinatorial Islet Autoantibody Workshop. Diabetes. 1998;47(December (12)):1857–1866
  2. Genovese S, Bazzigaluppi E, Goncalves D, Ciucci A, Cavallo MG, Purrello F, et al. Clinical phenotype and beta-cell autoimmunity in Italian patients with adult-onset diabetes. Eur. J. Endocrinol. 2006;154(March (3)):441–447
  3. Turner R, Stratton I, Horton V, Manley S, Zimmet P, Mackay IR, et al. UKPDS, 25, autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet. 1997;350(November 1 (9087)):1288–1293
  4. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(August 12 (7258)):405–412
  5. Fourlanos S, Perry C, Stein MS, Stankovich J, Harrison LC, Colman PG. A clinical screening tool identifies autoimmune diabetes in adults. Diab. Care. 2006;29(May (5)):970–975
  6. Zinman B, Kahn SE, Haffner SM, O’Neill MC, Heise MA, Freed MI. Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe. Diabetes. 2004;53(December (12)):3193–3200
  7. Lohmann T, Kellner K, Verlohren HJ, Krug J, Steindorf J, Scherbaum WA, et al. Titre and combination of ICA and autoantibodies to glutamic acid decarboxylase discriminate two clinically distinct types of latent autoimmune diabetes in adults (LADA). Diabetologia. 2001;44(August (8)):1005–1010
  8. Carlsson A, Sundkvist G, Groop L, Tuomi T. Insulin and glucagon secretion in patients with slowly progressing autoimmune diabetes (LADA). J. Clin. Endocrinol. Metab. 2000;85(January (1)):76–80
  9. Pietropaolo M, Barinas-Mitchell E, Pietropaolo SL, Kuller LH, Trucco M. Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes. Diabetes. 2000;49(January (1)):32–38
  10. Davis TM, Zimmet P, Davis WA, Bruce DG, Fida S, Mackay IR. Autoantibodies to glutamic acid decarboxylase in diabetic patients from a multi-ethnic Australian community: the Fremantle Diabetes Study. Diabet. Med. 2000;17(September (9)):667–674
  11. Monge L, Bruno G, Pinach S, Grassi G, Maghenzani G, Dani F, et al. A clinically orientated approach increases the efficiency of screening for latent autoimmune diabetes in adults (LADA) in a large clinic-based cohort of patients with diabetes onset over 50 years. Diabet. Med. 2004;21(May (5)):456–459
  12. Offringa M. Introduction to Evidence-Based-Medicine—Clinical Practise Based on Evidence. 2nd ed.. Houten/Antwerpen: Bohn Stafleu van Loghem; 2003;(in Dutch)
  13. Arikan E, Sabuncu T, Ozer EM, Hatemi H. The clinical characteristics of latent autoimmune diabetes in adults and its relation with chronic complications in metabolically poor controlled Turkish patients with type 2 diabetes mellitus. J. Diabet. Complications. 2005;19(September (5)):254–258
  14. Castleden HA, Shields B, Bingley PJ, Williams AJ, Sampson M, Walker M, et al. GAD antibodies in probands and their relatives in a cohort clinically selected for type 2 diabetes. Diabet. Med. 2006;23(August (8)):834–838
  15. Romkens TE, Kusters GC, Netea MG, Netten PM. Prevalence and clinical characteristics of insulin-treated, anti-GAD-positive, type 2 diabetic subjects in an outpatient clinical department of a Dutch teaching hospital. Neth. J. Med. 2006;64(April (4)):114–118

PII: S1751-9918(08)00077-6

doi: 10.1016/j.pcd.2008.08.003

Primary Care Diabetes
Volume 2, Issue 4 , Pages 207-211 , December 2008

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