Primary Care Diabetes
Volume 3, Issue 1 , Pages 5-15, February 2009

Clinical monitoring and management of the metabolic syndrome in patients receiving atypical antipsychotic medications

  • Mehrul Hasnain

      Affiliations

    • Department of Psychiatry, Western Regional Integrated Health Authority, Sir Thomas Roddick Hospital, Stephenville, Newfoundland, Canada
    • Corresponding Author InformationCorresponding author at: Sir Thomas Roddick Hospital, 142 Minnesota Drive, Stephenville, Newfoundland A2N 2V6, Canada. Tel.: +1 709 643 1973; fax: +1 709 643 7911.
    • ,
  • W. Victor R. Vieweg

      Affiliations

    • Psychiatry Services, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, United States
    • Medical Services, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, United States
    • Department of Psychiatry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, United States
    • Department of Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, United States
    • ,
  • Sonja K. Fredrickson

      Affiliations

    • Medical Services, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, United States
    • Department of Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, United States
    • ,
  • Mary Beatty-Brooks

      Affiliations

    • Medical Media, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, United States
    • ,
  • Antony Fernandez

      Affiliations

    • Psychiatry Services, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, United States
    • Department of Psychiatry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, United States
    • ,
  • Anand K. Pandurangi

      Affiliations

    • Department of Psychiatry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, United States

Received 26 June 2008; received in revised form 23 October 2008; accepted 24 October 2008. published online 11 December 2008.

Abstract 

Individuals with major mental illness are a high-risk group for cardio-metabolic derangements due to genetic predisposition, developmental and environmental stressors, and lifestyle. This risk is compounded when they receive antipsychotic medications. Guidelines for screening, monitoring, and managing these patients for metabolic problems have been in place for several years. Despite this, recent reports document that this population continues to receive poor care in this regard. In this article, we review the metabolic profile of atypical antipsychotic medications and offer guidelines to reduce the metabolic complications of these agents.

Keywords: Antipsychotic drugs, Overweight, Obesity, Diabetes mellitus, Dyslipidemia, Metabolic syndrome, Primary care

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PII: S1751-9918(08)00108-3

doi:10.1016/j.pcd.2008.10.005

Primary Care Diabetes
Volume 3, Issue 1 , Pages 5-15, February 2009

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