Primary Care Diabetes
Volume 4 , Pages S11-S18 , April 2010

Addressing barriers to initiation of insulin in patients with type 2 diabetes

  • Mark Peyrot

      Affiliations

    • Loyola University Maryland, Baltimore, Maryland, USA
    • Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    • Corresponding Author InformationCorresponding author. Mark Peyrot. Department of Sociology, Loyola University Maryland, 4501 North Charles Street, Baltimore, MD, 21210, USA. Tel.: +1 401 617 5140; fax: +1 410 617 2215
    • ,
  • Richard R. Rubin

      Affiliations

    • Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    • ,
  • Kamlesh Khunti

      Affiliations

    • Department of Health Sciences, University of Leicester, Leicester, UK

References 

  1. UK Prospective Diabetes Study (UKPDS) Group  . Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) . Lancet . 1998;352:837–853
  2. Holman RR , Paul SK , Bethel MA , et al.   10-year follow-up of intensive glucose control in type 2 diabetes . N. Engl. J Med. . 2008;359:1577–1589
  3. Ray KK , Seshasai SR , Wijesuriya S , et al.   Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials . Lancet . 2009;373:1765–1772
  4. Nathan DM , Buse JB , Davidson MB , et al.   Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes . Diabetes Care . 2006;29:1963–1972
  5. Turner RC , Cull CA , Frighi V , Holman RR . Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group . JAMA . 1999;281:2005–2012
  6. Qayyum R , Bolen S , Maruthur N , et al.   Systematic review: comparative effectiveness and safety of premixed insulin analogues in type 2 diabetes . Ann. Intern. Med. . 2008;149:549–559
  7. Rolla A . Pharmacokinetic and pharmacodynamic advantages of insulin analogues and premixed insulin analogues over human insulins: impact on efficacy and safety . Am. J Med. . 2008;121:S9–S19
  8. Raskin P . Efficacy and safety of insulin detemir, Endocrinol . Metab. Clin. North Am. . 2007;36(Suppl. 1):21–32
  9. Kamal AD , Dixon AN , Bain SC . Safety and side effects of the insulin analogues . Expert Opin. Drug Saf. . 2006;5:131–143
  10. Rubino A , McQuay LJ , Gough SC , et al.   Delayed initiation of subcutaneous insulin therapy after failure of oral glucose-lowering agents in patients with type 2 diabetes: a population-based analysis in the UK . Diabet. Med. . 2007;24:1412–1418
  11. Calvert MJ , McManus RJ , Freemantle N . Management of type 2 diabetes with multiple oral hypoglycaemic agents or insulin in primary care: retrospective cohort study . Br. J Gen. Pract. . 2007;57:455–460
  12. Nichols GA , Koo YH , Shah SN . Delay of insulin addition to oral combination therapy despite inadequate glycemic control: delay of insulin therapy . J. Gen. Intern. Med. . 2007;22:453–458
  13. Valensi P , Benroubi M , Borzi V , et al.   The IMPROVE study – a multinational, observational study in type 2 diabetes: baseline characteristics from eight national cohorts . Int. J Clin. Pract. . 2008;62:1809–1819
  14. Korytkowski M . When oral agents fail: practical barriers to starting insulin . Int. J Obes. Relat. Metab. Disord. . 2002;26(Suppl. 3):S18–S24
  15. Lustman PJ , Clouse RE . Depression in diabetic patients: the relationship between mood and glycemic control . J. Diabetes Complications . 2005;19:113–122
  16. Polonsky WH , Fisher L , Guzman S , et al.   Psychological insulin resistance in patients with type 2 diabetes: the scope of the problem . Diabetes Care . 2005;28:2543–2545
  17. Polonsky WH , Fisher L , Earles J , et al.   Assessing psychosocial distress in diabetes: development of the diabetes distress scale . Diabetes Care . 2005;28:626–631
  18. Brod M , Kongso JH , Lessard S , Christensen TL . Psychological insulin resistance: patient beliefs and implications for diabetes management . Qual. Life Res. . 2009;18:23–32
  19. Peyrot M . Psychological insulin resistance: overcoming barriers to insulin therapy . Pract. Diabetology . 2004;23:6–12
  20. Peyrot M , Rubin RR , Lauritzen T , et al.   Resistance to insulin therapy among patients and providers: results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study . Diabetes Care . 2005;28:2673–2679
  21. Diabetes Attitudes  , Wishes and Needs (DAWN) study  . Barriers to treatment . http://dawnstudy.com/documents/article_page/document/barriers.asp (accessed July 4, 2009).
  22. Davis SN , Renda SM . Psychological insulin resistance: overcoming barriers to starting insulin therapy . Diabetes Educ. . 2006;32(Suppl. 4):146S–152S
  23. Polonsky WH , Anderson BJ , Lohrer PA , et al.   Insulin omission in women with IDDM . Diabetes Care . 1994;17:1178–1185
  24. Hayes RP , Fitzgerald JT , Jacober SJ . Primary care physician beliefs about insulin initiation in patients with type 2 diabetes . Int. J Clin. Pract. . 2008;62:860–868
  25. Nakar S , Yitzhaki G , Rosenberg R , Vinker S . Transition to insulin in type 2 diabetes: family physicians' misconception of patients' fears contributes to existing barriers . J. Diabetes Complications . 2007;21:220–226
  26. Grant RW , Wexler DJ , Watson AJ , et al.   How doctors choose medications to treat type 2 diabetes: a national survey of specialists and academic generalists . Diabetes Care . 2007;30:1448–1453
  27. World Health Organization  . Self-management support for chronic conditions using 5As . www.who.int/entity/diabetesactiononline/about/WHO%205A%20ppt.pdf (accessed July 4, 2009).
  28. Peyrot M , Rubin RR . Behavioral and psychosocial interventions in diabetes: a conceptual review . Diabetes Care . 2007;30:2433–2440
  29. Orleans CT , Hutchinson D . Tailoring nicotine addiction treatments for chemical dependency patients . J. Subst. Abuse Treat. . 1993;10:197–208
  30. Snoek FJ , Skovlund SE , Pouwer F . Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes . Health Qual. Life Outcomes . 2007;5:69–75
  31. Blonde L , Merilainen M , Karwe V , et al.   Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue: an assessment of two different fasting plasma glucose targets – the TITRATE study . Diabetes Obes. Metab. . 2009;11:623–631
  32. Rubin RR . Adherence to pharmacologic therapy in patients with type 2 diabetes mellitus . Am. J Med. . 2005;118(Suppl. 5A):27S–34S
  33. Brunton S . Initiating insulin therapy in type 2 diabetes: benefits of insulin analogs and insulin pens . Diabetes Technol. Ther. . 2008;10:247–256
  34. Pfützner A . FlexPen® for the delivery of insulin: accuracy, injection force and patient preference . Expert Rev. Med. Devices . 2009;6:115–123
  35. Korytkowski M , Bell D , Jacobsen C , Suwannasari R . A multicenter, randomized, open-label, comparative, two-period crossover trial of preference, efficacy, and safety profiles of a prefilled, disposable pen and conventional vial/syringe for insulin injection in patients with type 1 or 2 diabetes mellitus . Clin. Ther. . 2003;25:2836–2848
  36. Asakura T , Seino H , Nakano R , et al.   A comparison of the handling and accuracy of syringe and vial versus prefilled insulin pen (FlexPen) . Diabetes Technol. Ther. . 2009;11:657–661
  37. Renders CM , Valk GD , Griffin SJ , et al.   Interventions to improve the management of diabetes mellitus in primary care, outpatient and community settings . Cochrane Database Syst. Rev. . 2000; CD001481.
  38. Siminerio LM , Funnell MM , Peyrot M , Rubin RR . US nurses' perceptions of their role in diabetes care: results of the cross-national Diabetes Attitudes Wishes and Needs (DAWN) study . Diabetes Educ. . 2007;33:152–162
  39. Piette JD , Weinberger M , Kraemer FB , McPhee SJ . Impact of automated calls with nurse follow-up on diabetes treatment outcomes in a Department of Veterans Affairs Health Care System: a randomized controlled trial . Diabetes Care . 2001;24:202–208
  40. Davis RE , Lowes L , Cradock S , et al.   Insulin initiation among adults and children with diabetes in the United Kingdom . Practical Diabetes Int. . 2006;23:171–174
  41. Goyder EC , McNally PG , Drucquer M , et al.   Shifting of care for diabetes from secondary to primary care, 1990–5: review of general practices . BMJ . 1998;316:1505–1506
  42. Khunti K , Ganguli S . Who looks after people with diabetes: primary or secondary care? . J. R. Soc. Med. . 2000;93:183–186
  43. Khunti K , Gadsby R , Millett C , et al.   Quality of diabetes care in the UK: comparison of published quality-of-care reports with results of the Quality and Outcomes Framework for Diabetes . Diabet. Med. . 2007;24:1436–1441
  44. Shojania KG , Ranji SR , McDonald KM , et al.   Effects of quality improvement strategies for type 2 diabetes on glycemic control: a meta-regression analysis . JAMA . 2006;296:427–440

PII: S1751-9918(10)60004-6

doi: 10.1016/S1751-9918(10)60004-6

Primary Care Diabetes
Volume 4 , Pages S11-S18 , April 2010

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