Primary Care Diabetes
Volume 4, Supplement 1 , Pages S19-S23, April 2010

Basal insulins: Pharmacological properties and patient perspectives

  • Martin J. Abrahamson

      Affiliations

    • Corresponding Author InformationCorrespondence: Martin J Abrahamson, MD FACP. Chief Medical Officer and Senior Vice President, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA. Tel: +1 617 732 2501; fax: +1 617 732 2574

Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA

Abstract 

Basal insulin analogues are an effective treatment for type 2 diabetes with proven efficacy, and insulins NPH, detemir and glargine have shown comparable glycaemic control. However, pharmacokinetics and clinical studies highlight the advantages of insulins detemir and glargine over insulin NPH in terms of once-daily dosing, reduced risk of hypoglycaemia, reduced within-patient variability, appropriate duration of action and simple titration. Insulin detemir has demonstrated the additional advantage of less weight gain. Introduction of insulin detemir, at the appropriate time, can help empower patients to reach glycaemic targets, with a reduced risk of hypoglycaemia and less weight gain.

Keywords:  Type 2 diabetes mellitus , Control , Basal insulin , Hypoglycaemia

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PII: S1751-9918(10)60005-8

doi:10.1016/S1751-9918(10)60005-8

Primary Care Diabetes
Volume 4, Supplement 1 , Pages S19-S23, April 2010

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