Primary Care Diabetes
Volume 4, Supplement 1 , Pages S31-S42, April 2010

Insulin detemir: A historical perspective on a modern basal insulin analogue

  • Luigi Meneghini

      Affiliations

    • University of Miami Miller School of Medicine, Miami, Florida, USA
    • Corresponding Author InformationCorresponding author. Luigi Meneghini. Division of Endocrinology & Diabetes, University of Miami School of Medicine, Diabetes Research Institute, 1450 NW 10th Avenue, Miami, Florida 33136, USA. Tel.: +1 305-243-5366; fax: +1 305-243-1200
    • ,
  • Andreas Liebl

      Affiliations

    • Center for Diabetes and Metabolism, Fachklinik, Bad Heilbrunn, Germany
    • ,
  • Martin J. Abrahamson

      Affiliations

    • Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA

Abstract 

Insulin detemir provides prolonged, reproducible blood glucose reduction through a mechanism unique among basal insulins. It was originally studied clinically in predominantly basal + bolus regimens and found to be associated with a low risk of hypoglycaemia compared to insulin NPH, and reduced weight gain compared to other basal insulins. Insulin detemir has been increasingly studied in basal-only insulin regimens in type 2 diabetes, in which an understanding of how to optimize its use has been built incrementally. Glycaemic control and limitation of weight gain tend to be maximized by once-daily (evening) dosing, earlier initiation and careful titration to appropriate fasting glucose targets.

Keywords:  Insulin detemir , Basal insulin analogue , Hypoglycemia , Weight gain

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PII: S1751-9918(10)60007-1

doi:10.1016/S1751-9918(10)60007-1

Primary Care Diabetes
Volume 4, Supplement 1 , Pages S31-S42, April 2010

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