Highlights
- •Garlic has significantly beneficial effect on lipid profile parameters.
- •Garlic have significantly effect on improving serum levels of fasting blood glucose.
- •Garlic have significantly effect on improving serum levels of glycosylated hemoglobin.
- •Garlic has beneficial effects in improving the outcomes of cardiovascular disease and diabetes.
Abstract
Purpose
Several studies have been published about the effect of garlic on lipid profile and
blood glucose in diabetic patients. Which, the results mostly contradict with each
other. This study aimed to investigate the effect of garlic on lipid profile and serum
glucose levels in diabetic patients using a systematic review and meta-analysis.
Methods
This study was a systematic review and meta-analysis of articles published between
1988 and 2016. For this purpose, two independent researchers searched SID medical
information databases including MagIran, Irandoc, Medlib, Iran Medex, Science Direct,
Scopus, Google and PubMed using keywords. Data were analyzed using STATA software.
Results
After the initial search, 23,000 articles were found, of which 33 had the required
criteria for the meta-analysis. In the present study, the total sample under review
was 1273 individuals, with a mean of 39 samples per study. Overall, the garlic was
more influential than placebo in reducing the levels of lipid parameters including
triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density
lipoprotein (LDL), and fasting blood sugar (FBS) and HbA1C. In the meta-analysis, the concentration of serum TC, LDL, TG, and HDL in the group
receiving garlic compared with the placebo showed a significant decreased for 16.87 mg/dl (95% CI, −21.01, −12.73) (P = 0.001), 9.65 mg/dl (95% CI, −15.07, −4.23) (P = 0.001), 12.44 mg/dl (95% CI, −18.19, −6.69) (P = 0.001), and increased for 3.19 mg/dl (95% CI, 1.85, 4.53) (P = 0.001), respectively. Also, the concentration of serum FBS and HbA1C serum showed a significant decreased for 10.90 mg/dl (95% CI, −16.40, −5.40) (P = 0.001) and 0.60 mg/dl (95% CI, −0.98, −0.22) (P = 0.001), respectively.
Conclusion
Garlic can reduce lipid profile as well as glucose parameters and be therapeutically
effective in patients suffering from cardiovascular diseases and diabetes.
Keywords
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References
- Frequent outpatient contact and decreasing medication affordability in patients with diabetes from 1997 to 2004.Diabetes Care. 2006; 29: 1386-1388
- Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections.Diabetes Care. 1998; 21: 1414-1431
- Insulin resistance and atherosclerosis.Diabetes Rev. 1997; 5: 331-342
- Salt reduction and cardiovascular risk: the anatomy of a myth.J. Hum. Hypertens. 1999; 13: 1
- Andreoli and Carpenter’s Cecil Essentials of Medicine.5th ed. W. B. Saunders, Philadelphia2001: 103-113
- Pathogenesis of macrovascular disease in diabetes.Joslin's Diabetes Mellit. 1994; : 648-664
- 7th ed. Herbal Treatment. 13-15. Diba Printer, Argmand: Tehran1997: 330-335
- What do herbalists suggest to diabetic patients in order to improve glycemic control? Evaluation of scientific evidence and potential risks.Acta Diabetol. 2004; 41: 91-98
- Effect of garlic on cardiovascular disorders: a review.Nutr. J. 2002; 1: 4
- Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats.Biosci. Rep. 2001; 21: 19-24
- The effects of liquid extract of Allium sativum on the basic and speed-dependent electrophysiological properties of islolated atrioventicular nodal of rabbit.J. Shahrekord Univ. Med. Sci. 2007; : 2007
- Therapeutic actions of garlic constituents.Med. Res. Rev. 1996; 16: 111-124
- Prevalence of diabetes and impaired fasting glucose in the adult population of Iran: national survey of risk factors for non-communicable diseases of Iran.Diabetes Care. 2008; 31: 96-98
- Garlic as an anti-diabetic agent: recent progress and patent reviews.Recent Pat. Food Nutr. Agric. 2013; 5: 105-127
- Garlic as an antioxidant: the good, the bad and the ugly.Phytother. Res. 2003; 17: 97-106
- Antimicrobial effects of Allium sativum L. (garlic), Allium ampeloprasum L. (elephant garlic), and Allium cepa L. (onion), garlic compounds and commercial garlic supplement products.Phytother. Res. 1991; 5: 154-158
- Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease.Prostaglandins, Leukot. Essent. Fatty Acids. 1998; 58: 257-263
- The effect of dried garlic powder tablets on serum lipids in non-insulin dependent diabetic patients.Eur. J. Clin. Res. 1996; 8: 25-26
- Effect of dried garlic supplementation on blood lipids in mild and moderate hypercholesterolemic patients.Arch. Iran. Med. 1999; 2: 19-23
- Modulation of lipid profile by fish oil and garlic combination.J. Natl. Med. Assoc. 1997; 89: 673
- Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects.J. Nutr. 2001; 131: 1471-1478
- Study of garlic extracts and fractions on cholesterol plasma levels and vascular reactivity in cholesterol-fed rats.J. Nutr. 2001; 131: 994S-999S
- High hydrostatic pressure extract of garlic increases the HDL cholesterol level via up-regulation of apolipoprotein AI gene expression in rats fed a high-fat diet.Lipids Health Dis. 2012; 11: 77
- Can garlic reduce levels of serum lipids? A controlled clinical study.Am. J. Med. 1993; 94: 632-635
- Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds.Cancer Lett. 2008; 269: 305-314
- Free-radical scavenging capacity and antioxidant properties of some selected onions (Allium cepa L.) and garlic (Allium sativum L.) extracts.Braz. Arch. Biol. Technol. 2005; 48: 753-759
- Aged garlic extract improves endothelial function in men with coronary artery disease.Phytother. Res. 2005; 19: 314-319
- Effects of acute and subacute garlic supplement administration on serum total antioxidant capacity and lipid parameters in healthy volunteers.Phytother. Res. 2010; 24: 374-378
- No effect of garlic extract supplement on serum lipid levels in hypercholesterolemic subjects.J. Med. Assoc. Thai. 2003; 86: 750-757
- Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism: a randomized controlled trial.JAMA. 1998; 279: 1900-1902
- Including garlic in the diet may help lower blood glucose, cholesterol, and triglycerides.J. Nutr. 2006; 136: 800S-802S
- Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats.Food Chem. Toxicol. 2005; 43: 57-63
- Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors.Int. J. Clin. Pharmacol. Therapy Toxicol. 1991; 29: 151-155
- Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin.Comp. Biochem. Physiol. A: Mol. Integr. Physiol. 2003; 135: 539-547
- Effect of garlic on blood lipids in patients with coronary heart disease.Am. J. Clin. Nutr. 1981; 34: 2100-2103
- Effect of garlic tablet on blood glucose in type 2 diabetic patients.Sci. J. Faize. 2007; 11: 20-25
- Evaluation the effect garlet tablet on serum lipid profile.Avicenna J. Clin. Med. 2006; 13: 37-40
- The effect of garlic tablet on blood glucose, and lipid profile in type 2 diabetic patients&58; a double-blind randomized placebo controlled trial.J. Shahid Sadoughi Univ. Med. Sci. 2015; 23: 621-630
- The effect of garlic tablet on blood glucose, and lipid profile in type 2 diabetic patients: a double-blind randomized placebo controlled trial.J. Shahid Sadoughi Univ. Med. Sci. 2015; 23: 621-630
- Effects of garlic tablet on blood sugar, plasma lipids and blood pressure in type 2 diabetic patients with hyperlipidemia.J. Med. Plants. 2006; 1: 48-54
- The concurrent effect of one bout aerobic exercise and short-term garlic supplementation on the lipids profile in male non-athletes.J. Shahrekord Univ. Med. Sci. 2012; 14: 34-41
- The effects of consumption of raw garlic on serum lipid level, blood sugar and a number of effective hormones on lipid and sugar metabolism in hyperglycemic and/or hyperlipidemic individuals—benefit of raw garlic consumption.Adv. Biol. Chem. 2011; 1: 29
- Effect of raw garlic on blood biochemical factors in hyperlipidemic and.Bimonthly J. Hormozgan Univ. Med. Sci. 2007; 11: 127-131
- Effect of raw garlic on blood biochemical factors in hyperlipidemic and high blood sugar.Hormozgan Univ. Med. Sci. 2007; 11: 127-131
- The effect of regular aerobic exercise and garlic supplementation on lipid profile and blood pressure in inactive subjects.Zahedan J. Res. Med. Sci. 2015; 17
- Effect of garlic and lemon juice mixture on lipid profile and some cardiovascular risk factors in people 30–60 years old with moderate hyperlipidaemia: a randomized clinical trial.Int. J. Prev. Med. 2016; 7
- Comparison between swallowing and chewing of garlic on levels of serum lipids, cyclosporine, creatinine and lipid peroxidation in renal transplant recipients.Lipids Health Dis. 2005; 4: 11
- Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemia.Atherosclerosis. 1988; 74: 247-249
- Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol.J. Nutr. Biochem. 2004; 15: 373-377
- Allium sativum essential oil (ASEO); effect of supplementation on serum triglycerides, total, cholesterol, HDLC, LDLC and blood cell counts in albino rats.Prof. Med. J. 2017; 24
- Cholesterol lowering property of garlic (Allium sativum) on patients with hypercholesterolemia.Int. J. Med. Sci. Public Health. 2016; 5: 2249-2251
- The effect of a garlic preparation on plasma lipid levels in moderately hypercholesterolemic adults.Atherosclerosis. 2001; 154: 213-220
- Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: the results of double-blinded placebo-controlled study.Acta Diabetol. 2008; 45: 1-6
Z.M. Hussien, L.T. Ahmed, Q.G. Hussain, Effect of Atorvastatin And Garlic on Lipid Profile in Hyperlipidemic Patients.
- Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men.Am. J. Clin. Nutr. 1997; 65: 445-450
- Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus.J. Ayub Med. Coll. Abbottabad. 2005; 17: 60-64
- A pilot study of garlic consumption shows no significant effect on markers of oxidation or sub-fraction composition of low-density lipoprotein including lipoprotein (a) after allowance for non-compliance and the placebo effect.Clin. Chim. Acta. 1999; 285: 21-33
- Reduction of blood lipid parameters by a 12-wk supplementation of aged black garlic: a randomized controlled trial.Nutrition. 2014; 30: 1034-1039
- Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women.Nutr. Res. Pract. 2012; 6: 226-231
- Aged garlic supplement protects against lipid peroxidation in hypercholesterolemic individuals.J. Med. Food. 2016; 19: 931-937
- Garlic extract therapy in children with hypercholesterolemia.Arch. Pediatr. Adolesc. Med. 1998; 152: 1089-1094
- Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein (a).J. Am. Coll. Cardiol. 2000; 35: 321-326
- Effects of garlic ingestion with breakfast on postprandial serum glucose and insulin in type 2 diabetic patients.Iran. J. Nutr. Sci. Food Technol. 2007; 1: 39-44
- New treatment options for lipid-lowering therapy in subjects with type 2 diabetes.Acta Diabetol. 2017; : 1-10
- Lipid-modifying effects of nutraceuticals: an evidence-based approach.Nutrition. 2016; 32: 1179-1192
- Effect of garlic on plasma lipoprotein (a) concentrations: a systematic review and meta-analysis of randomized controlled clinical trials.Nutrition. 2016; 32: 33-40
- Lipid-lowering nutraceuticals in clinical practice: position paper from an International lipid expert panel.Nutr. Rev. 2017; 75: 731-767
- The role of nutraceuticals in the prevention of cardiovascular disease.Cardiovasc. Diagn. Ther. 2017; 7: S21
Article info
Publication history
Published online: July 23, 2018
Accepted:
July 1,
2018
Received in revised form:
June 13,
2018
Received:
March 28,
2018
Identification
Copyright
© 2018 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
