Abstract
Aims
We investigated to clarify factors associated with the efficacy of sitagliptin, a
dipeptidyl peptidase (DPP)-IV inhibitor, for glycemic control including the confounding
effect of concomitant drugs in patients with type 2 diabetes.
Methods
We included type 2 diabetes patients with HbA1c levels of ≥7% who were not under insulin
treatment and were administered sitagliptin (50 mg/day for 6 months). Reduction or discontinuation of insulin sensitizers was not
permitted during the study period. Outcomes included HbA1c level variations and attaining
a target HbA1c level of <7%. Associated factors with each outcome were examined using
multivariate analysis.
Results
Of the 313 patients enrolled in this study, 147 (47.0%) attained HbA1c levels of <7%.
High baseline HbA1c levels were associated with HbA1c level variations but inversely
associated with attaining the target HbA1c level of <7%. Concomitant use of an insulin
sensitizer and a α-glucosidase inhibitor and maintenance of the baseline dose of concomitant
drugs were significantly associated with each outcome.
Conclusions
Our results suggest that concomitant sitagliptin administration (50 mg/day) will improve glycemic control if treatment is initiated before HbA1c levels
deteriorate. Other medication should be continued at initiation of sitagliptin administration.
Keywords
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Article info
Publication history
Published online: February 18, 2014
Accepted:
January 18,
2014
Received:
December 16,
2013
Identification
Copyright
© 2014 Primary Care Diabetes Europe. Published by Elsevier Inc. All rights reserved.
