Abstract
Aims
In published studies metformin was often associated with weight loss in type 2 diabetes
patients. Until now, no epidemiological studies have directly compared the effects
of DPP-4 and GLP-1 versus metformin on weight loss. Our study is a comparison of sulfonylurea,
DPP-4 and GLP-1 with metformin regarding body weight in type 2 diabetes patients.
Methods
Data from 2641 patients initiated therapy with either metformin, sulfonylurea, DPP-inhibitors
or GLP-1 with baseline BMI >30 were retrospectively analyzed (Disease Analyzer Germany:
11/2008–10/2012). Comparison was performed for the weight change after 1 year of therapy
compared with the last value prior to therapy. Differences between SU, DPP-4, GLP-1
versus metformin were estimated using regression model adjusted for age, gender, health
insurance status, defined co-diagnoses and body weight at baseline.
Results
In absolute values, metformin patients lost an average of 2.6 kg, subjects treated with SU gained 0.3 kg, body weight in the DPP-4 group decreased by 1.8 kg and GLP-1 patients lost 3.3 kg in body weight after 1 year. After adjustment for other variables, comparisons
with metformin revealed the following results: SU +3.4 kg (p < 0.001), DPP-4 +1.0 kg (p = 0.003) and GLP-1 −0.4 kg (p = 0.589).
Conclusion
Our study showed that GLP-1 treatment was comparable to metformin regarding the weight
reduction, while sulfonylurea and DPP-4 are inferior in this regard.
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Article info
Publication history
Published online: May 06, 2014
Accepted:
April 1,
2014
Received in revised form:
March 27,
2014
Received:
February 8,
2014
Identification
Copyright
© 2014 Primary Care Diabetes Europe. Published by Elsevier Inc. All rights reserved.
