Abstract
Aims
To assess the effect of physical activity in patients with type 2 diabetes mellitus
on prevention of diabetes with chronic kidney disease.
Methods
This is a cohort study on stratified selected subjects in Taiwan from 2004/01/01 to
2005/12/31. Demographic data, lifestyle factors and clinical characteristics were
analyzed for an association with the occurrence of chronic kidney disease. Applicable
analysis weights, Stata 11.0, were applied to adjust the design variables for clustering
and stratification.
Results
During the two year study period, the univariate Cox proportional hazards model showed
significant associations of age, physical activity, and the Charlson comorbidity index
(CCI) with chronic kidney disease. Physical activity had a beneficial effect in diabetic
subjects with chronic kidney disease (HR: 0.31, p < 0.01). Older age and a CCI greater than 2 were both harmful in diabetic subjects with
chronic kidney disease (1.06 and 3.44, respectively). The results of a multivariate
Cox proportional hazards evaluation model were similar to those of a univariate evaluation
model, except that CCI was not significantly different. Moreover, medications for
hypertension of diabetic subjects created an increased risk of chronic kidney disease
(HR: 5.85 and 3.74, respectively), indicating that the presence of hypertension is
a strong risk factor for the progression of chronic kidney disease.
Conclusion
In this study, physical activity was not only a healthful lifestyle factor but also
a treatment to decrease incidence of chronic kidney disease in diabetic patients.
Abbreviations:
CCI (Charlson comorbidity index), CHF (chronic heart failure), CKD (chronic kidney disease), CVD (cardiovascular disease), ESRD (end-stage renal disease), UAE (urinary albumin excretion)Keywords
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Article info
Publication history
Published online: May 06, 2014
Accepted:
April 6,
2014
Received in revised form:
March 27,
2014
Received:
January 9,
2014
Identification
Copyright
© 2014 Primary Care Diabetes Europe. Published by Elsevier Inc. All rights reserved.
