Highlights
- •Inflammatory markers predict incident type-2 diabetes.
- •Inflammation plays a role for the development of diabetes complications.
- •The association between sialic acid and incident diabetes has been studied.
- •87,035 men and women have been followed-up in national registers.
- •Sialic acid is independently associated with risk of incident diabetes.
Abstract
Aim
To examine the association of sialic acid (SA) with first recorded diabetes mellitus-related
hospitalization.
Methods
From a population-based study in Värmland, Sweden, between 1962 and 1965, 87,035 men
and women were selected and followed for first recorded diabetes-related hospitalization
until 2005. The association of SA was calculated and stratified for gender by Cox's
proportional hazards models. Adjustments were made for conventional risk factors and
socioeconomic status. Association analyses were made for comparisons between SA-levels
above and below median.
Results
The mean age was 47.2 (SD 13.0) years and the total numbers of incident diabetes-related
hospitalizations in men and women were 3445 and 3273, respectively. Hazard ratios
per one standard deviation of SA were 1.12 (95% CI: 1.08–1.17, p < 0.0001) in men and 1.17 (95% CI: 1.13–1.22, p < 0.0001) in women. Interaction analyses indicated a relatively higher SA-associated
risk in women than in men with above median SA levels.
Conclusions
In this large population-based cohort followed for more than 40 years, elevated SA,
as a marker of systemic inflammation, was independently associated with risk of diabetes
and diabetes-related hospitalizations.
Keywords
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Article info
Publication history
Published online: July 01, 2014
Accepted:
June 3,
2014
Received in revised form:
May 9,
2014
Received:
July 3,
2013
Identification
Copyright
© 2014 Primary Care Diabetes Europe. Published by Elsevier Inc. All rights reserved.
