Highlights
- •The study included 72,148 type 2 diabetes patients and 72,148 non-diabetic controls.
- •3.4% of diabetes patients and 2.8% of controls developed psoriasis within ten years of follow-up.
- •Diabetes was positively associated with psoriasis in German primary care practices.
Abstract
Aim
To analyze psoriasis risk in type 2 diabetes mellitus (T2DM) patients treated in German
primary care practices.
Methods
The study included 87,964 T2DM patients aged 40 years or over who received their initial
diabetes diagnosis between 2004 and 2013. Patients were excluded if they had been
diagnosed with psoriasis prior to diabetes diagnosis or if the observation period
prior to the index date was less than 365 days. After applying these exclusion criteria,
72,148 T2DM patients were included. A total of 72,148 non-diabetic controls were matched
(1:1) to T2DM cases based on age, gender, type of health insurance (private or statutory),
number of medical visits, and index date. The primary outcome was the diagnosis of
psoriasis. Skin infections, dermatitis/eczema, hyperlipidemia, and medications associated
with psoriasis (beta blockers, angiotensin-converting enzyme (ACE) inhibitors, lithium,
antimalarials, nonsteroidal anti-inflammatory drugs, and benzodiazepines) were included
as potential confounders.
Results
The mean age was 68.7 years (SD = 12.7 years) and 48.6% of subjects were men. Hyperlipidemia, dermatitis/eczema, and
skin infections were more frequent in T2DM patients than in controls. Beta blockers,
ACE inhibitors, and nonsteroidal anti-inflammatory drugs were also more commonly used
in people with T2DM than in controls. A total of 3.4% of T2DM patients and 2.8% of
matched controls developed psoriasis within ten years of follow-up (p-value <0.001). T2DM patients were at a higher risk of developing psoriasis than controls
(HR = 1.18, 95% CI: 1.08–1.29).
Conclusion
T2DM was positively associated with psoriasis in patients treated in German primary
care practices.
Keywords
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Article info
Publication history
Published online: July 23, 2016
Accepted:
July 10,
2016
Received in revised form:
June 11,
2016
Received:
March 25,
2016
Identification
Copyright
© 2016 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
