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Relationship between the Finnish Diabetes Risk Score (FINDRISC), vitamin D levels, and insulin resistance in obese subjects

Published:December 01, 2016DOI:https://doi.org/10.1016/j.pcd.2016.11.001

      Highlights

      • LA-FINDRISC was associated with VD plasma concentrations.
      • Subjects with an increased risk of T2D had a greater degree of insulin resistance.
      • VD levels alone may not be sufficient to determine T2D risk.

      Abstract

      Aim

      To assess the relationship between 25-hydroxyvitamin D [25(OH)D] blood concentrations in subjects with obesity and type 2 diabetes mellitus (T2D) risk according to the Finnish Diabetes Risk Score (FINDRISC) modified for Latin America (LA-FINDRISC).

      Methods

      This study was conducted in Ciudad Bolívar, Venezuela. Eighty two women and 20 men (53 obese and 49 nonobese), with an average age of 42.6 ± 12.30 years were enrolled. Weight, height, body mass index (BMI), waist circumference (WC), fasting glucose, basal insulin, plasma lipids, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), and 25(OH)D levels were measured. FINDRISC with WC cutoff points modified for Latin America was applied.

      Results

      No difference in 25(OH)D levels between obese and nonobese subjects was found. When anthropometric, clinical, and biochemical variables according to the 25(OH)D status were compared, the only difference detected was higher LA-FINDRISC in the insufficient/low 25(OH)D group compared to normal 25(OH)D levels group (12.75 ± 6.62; vs 10.15 ± 5.21; p = 0.031). LA-FINDRISC was negatively correlated with plasma 25(OH)D levels (r = −0.302; p = 0.002) and positively correlated with the HOMA-IR index (r = 0.637; p = 0.0001).

      Conclusions

      The LA-FINDRISC significantly correlated with both 25(OH)D levels and insulin resistance markers in this group of patients.

      Keywords

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