Highlights
- •Obstructive sleep apnea was an independent risk factor for diabetic neuropathy.
- •Obstructive sleep apnea was significantly correlated with type I diabetic neuropathy.
- •Obstructive sleep apnea was not markedly correlated with type II diabetic neuropathy.
Abstract
Background
The aim of this study was to explore the correlation between obstructive sleep apnea
(OSA) and diabetic neuropathy.
Materials and methods
After working out searching strategy, literatures were screened from the electronic
databases: PubMed, Embase, and the Cochrane library. R 3.12 was utilized to perform
meta-analysis, and odds ratio (OR) and its 95% confidence interval (CI) were used
to present effect size. Heterogeneity was assessed by χ2-based Q test and I2 statistics. Publication bias was estimated by Egger’s test and sensitivity was evaluated
by leave one out methods.
Results
According to the criteria, a total of 11 studies with 1842 patients were enrolled
in this study. With a significant heterogeneity (Q = 31.83, I2 = 68.60%), the random effects model was utilized to assess the effect size of pooled
data. A remarkable correlation was identified OSA and diabetic neuropathy (OR = 1.84, 95% CI: 1.18–2.87) without publication bias (t = 1.68, P = 0.13). Meanwhile, the result of leave one out performed a well sensitivity. Moreover,
the subgroup analyses presented that OSA was significantly correlated with type 1
diabetic neuropathy (OR = 1.97, 95% CI: 1.19–3.25), but no remarkable correlation was identified between OSA
and type 1 (OR = 1.84, 95% CI: 0.86–3.93) or 1 + 2 (OR = 1.30, 95% CI: 0.43–3.92) diabetic neuropathy.
Conclusion
OSA was significantly correlated with neuropathy in type 1 diabetes, but not in type
2 and type 1 + 2 diabetes.
Keywords
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Article info
Publication history
Published online: May 01, 2018
Accepted:
March 24,
2018
Received in revised form:
March 13,
2018
Received:
January 9,
2018
Identification
Copyright
© 2018 Published by Elsevier Ltd on behalf of Primary Care Diabetes Europe.
