Sex disparities in cardiovascular disease outcomes among geriatric patients with prediabetes

      Highlights

      • Older prediabetic males have worse in-hospital cardiovascular outcomes and survival than females.
      • The admission rate was higher among older white males and female with prediabetes than other racial groups.
      • Older males with prediabetes have a higher prevalence of overall cardiovascular comorbidities.
      • Hypertension and Obesity frequencies were higher in older prediabetic females than males.
      • Geriatric prediabetic males reported higher frequency of acute MI, arrhythmia, stroke, PCI and thromboembolism than females.

      Abstract

      Aims

      To analyze the sex-based differences in the prevalence of cardiovascular disease risk factors and outcomes in older patients with prediabetes using demographically matched national cohorts of hospitalized patients aged ≥65 years.

      Methods

      We queried the 2007–2014 National Inpatient Database to identify older patients (>65 years) admitted with prediabetes using ICD-9 Clinical Modification codes. The older patients were then subcategorized based on sex. Comparative analyses of their baseline characteristics, the prevalence of cardiovascular(CV) disease comorbidities, hospitalization outcomes, and mortality rates were performed on propensity-matched cohorts for demographics.

      Results

      A total of 1,197,978 older patients with prediabetes (599,223 males; mean age 75years and 598,755 females; mean age 76years) were identified. Higher admission rates were found commonly among older white males (84.1%) and females (81.7%). Prediabetic older males showed a higher frequency of cardiovascular comorbidities compared to females. Prediabetic older males had higher all-cause in-hospital mortality (4.2% vs. 3.6%, p < 0.001), acute myocardial infarction (7.0% vs. 4.7%, p < 0.001), arrhythmia (36.3% vs. 30.5%, p < 0.001), stroke (4.8% vs. 4.6%, p < 0.001), venous thromboembolism (3.3% vs. 3.0%, p < 0.001) and percutaneous coronary intervention (3.1% vs. 1.5%, p < 0.001) compared to females.

      Conclusions

      Our analysis revealed that among older patients hospitalized with prediabetes, males suffered worse in-hospital CV outcomes and survival rates compared to females.

      Keywords

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