Preexisting prediabetes and the severity of COVID-19

Published:September 09, 2020DOI:https://doi.org/10.1016/j.pcd.2020.09.002
      The emergence of a novel coronavirus disease (COVID-19) in Wuhan, China, is spreading rapidly across the globe. A frequent preexisting comorbidity in COVID-19 patients is type 2 diabetes [
      • Wang X.
      • Wang S.
      • Sun L.
      • Qin G.
      Prevalence of diabetes mellitus in 2019 novel coronavirus: a meta-analysis.
      ]. Several reports published in Primary Care Diabetes and elsewhere have consistently shown that preexisting type 2 diabetes is associated with the disease severity of COVID-19. This includes increased episodes of acute respiratory distress syndrome, intensive care unit admission, mechanical ventilation, and mortality [
      • Apicella M.
      • Campopiano M.C.
      • Mantuano M.
      • Mazoni L.
      • Coppelli A.
      • Del Prato S.
      COVID-19 in people with diabetes: understanding the reasons for worse outcomes.
      ,
      • Varikasuvu S.R.
      • Dutt N.
      • Thangappazham B.
      • Varshney S.
      Diabetes and COVID-19: a pooled analysis related to disease severity and mortality.
      ]. However, the impact of preexisting prediabetes on the course of this disease is far less well studied.
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      References

        • Wang X.
        • Wang S.
        • Sun L.
        • Qin G.
        Prevalence of diabetes mellitus in 2019 novel coronavirus: a meta-analysis.
        Diabetes Res. Clin. Pract. 2020; 164https://doi.org/10.1016/j.diabres.2020.108200
        • Apicella M.
        • Campopiano M.C.
        • Mantuano M.
        • Mazoni L.
        • Coppelli A.
        • Del Prato S.
        COVID-19 in people with diabetes: understanding the reasons for worse outcomes.
        Lancet Diabetes Endocrinol. 2020; 8: 782-792
        • Varikasuvu S.R.
        • Dutt N.
        • Thangappazham B.
        • Varshney S.
        Diabetes and COVID-19: a pooled analysis related to disease severity and mortality.
        Prim. Care Diabetes. 2020; (ahead of print)https://doi.org/10.1016/j.pcd.2020.1008.1015
        • Grossmann V.
        • Schmitt V.H.
        • Zeller T.
        • Panova-Noeva M.
        • Schulz A.
        • Laubert-Reh D.
        • Juenger C.
        • Schnabel R.B.
        • Abt T.G.
        • Laskowski R.
        • Wiltink J.
        • Schulz E.
        • Blankenberg S.
        • Lackner K.J.
        • Münzel T.
        • Wild P.S.
        Profile of the immune and inflammatory response in individuals with prediabetes and type 2 diabetes.
        Diabetes Care. 2015; 38: 1356-1364
        • Li H.
        • Tian S.
        • Chen T.
        • Cui Z.
        • Shi N.
        • Zhong X.
        • Qiu K.
        • Zhang J.
        • Zeng T.
        • Chen L.
        • Zheng J.
        Newly diagnosed diabetes is associated with a higher risk of mortality than known diabetes in hospitalized patients with COVID-19.
        Diabetes Obes. Metab. 2020; (ahead of print)https://doi.org/10.1111/dom.14099
        • Smith S.M.
        • Boppana A.
        • Traupman J.A.
        • Unson E.
        • Maddock D.A.
        • Chao K.
        • Dobesh D.P.
        • Brufsky A.
        • Connor R.I.
        Impaired glucose metabolism in patients with diabetes, prediabetes, and obesity is associated with severe COVID-19.
        J. Med. Virol. 2020; (ahead of print)https://doi.org/10.1002/jmv.26227
        • Sathish T.
        • Cao Y.
        • Kapoor N.
        Newly diagnosed diabetes in COVID-19.
        Prim. Care Diabetes. 2020; (ahead of print)https://doi.org/10.1016/j.pcd.2020.1008.1014
      1. International Diabetes Federation, IDF Diabetes Atlas, Brussels, Belgium, 2019.