Association between serum uric acid levels and cardiovascular events in hospitalized patients with type 2 diabetes

  • Zhan Chang
    Affiliations
    Department of Endocrinology, Peking University People’s Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China

    Department of Endocrinology, Second Hospital of Shijiazhuang, 53 Huaxi Road, Shijiazhuang, Hebei, 050000, China
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  • Xiang-hai Zhou
    Correspondence
    Corresponding author at: Department of Endocrinology, Peking University People’s Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
    Affiliations
    Department of Endocrinology, Peking University People’s Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China
    Search for articles by this author
  • Xin Wen
    Affiliations
    Department of Endocrinology, Peking University People’s Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China
    Search for articles by this author
Published:April 10, 2021DOI:https://doi.org/10.1016/j.pcd.2021.03.003

      Highlights

      • Retrospective study of hospitalized type 2 diabetes patients.
      • Uric acid level in women is associated with cardiovascular events.
      • Uric acid level in men is not associated with cardiovascular events.

      Abstract

      Aims

      This study aimed to determine the association between serum uric acid (UA) levels and cardiovascular events in hospitalized patients with type 2 diabetes mellitus (T2DM).

      Methods

      A retrospective cohort study was conducted in 2227 hospitalized patients with T2DM. Cox proportional hazards regression was used to assess the association between serum UA and cardiovascular events, including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, heart failure, unstable angina, and arrhythmias requiring hospitalization.

      Results

      Among 1314 men, 143 (10.9%) experienced cardiovascular events. Serum UA level was not associated with the risk of cardiovascular events (hazard ratio [HR] per 100 μmol/L increase in serum UA: 1.12, 95% confidence interval [CI]: 0.90–1.40). Among 913 women, 96 (10.5%) experienced cardiovascular events. For every 100 μmol/L increase in serum UA level, the risk of experiencing a cardiovascular event increased by 27% (HR: 1.27, 95% CI: 1.02–1.57).

      Conclusions

      In hospitalized patients with T2DM, baseline serum UA levels were positively associated with cardiovascular events in women, but not in men. Serum UA levels may be a significant independent risk factor for cardiovascular events in women with T2DM.

      Keywords

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