Mean platelet volume may not be responsible for increased male mortality in diabetic patients with severe coronavirus disease

Published:August 02, 2021DOI:https://doi.org/10.1016/j.pcd.2021.07.014
      We have carefully read the retrospective study of Hammad and Alseoudy claiming that they found some laboratory abnormalities that predispose to higher mortality in male patients with diabetes mellitus than female patients with severe Coronavirus disease (COVID-19) [
      • Hammad M.O.
      • Alseoudy M.M.
      The sex-related discrepancy in laboratory parameters of severe COVID-19 patients with diabetes: a retrospective cohort study.
      ]. The researchers found lower mean platelet volume (MPV) and higher MPV/lymphocyte ratio in male patients compared to women, blaming these results for the higher male mortality rate. We think that there are other factors that may have negatively affected the results of this study.

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      References

        • Hammad M.O.
        • Alseoudy M.M.
        The sex-related discrepancy in laboratory parameters of severe COVID-19 patients with diabetes: a retrospective cohort study.
        Prim. Care Diabetes. 2021; https://doi.org/10.1016/j.pcd.2021.05.002
        • Noris P.
        • Melazzini F.
        • Balduini C.L.
        New roles for mean platelet volume measurement in the clinical practice?.
        Platelets. 2016; 27: 607-612https://doi.org/10.1080/09537104.2016.1224828
        • Jackson S.R.
        • Carter J.M.
        Platelet volume: laboratory measurement and clinical application.
        Blood Rev. 1993; 7: 104-113https://doi.org/10.1016/s0268-960x(05)80020-7
        • Beyan C.
        • Beyan E.
        Were the measurements standardized sufficiently in published studies about mean platelet volume?.
        Blood Coagul. Fibrinolysis. 2017; 28: 234-236https://doi.org/10.1097/MBC.0000000000000586
        • Lancé M.D.
        • van Oerle R.
        • Henskens Y.M.
        • Marcus M.A.
        Do we need time adjusted mean platelet volume measurements?.
        Lab. Hematol. 2010; 16: 28-31https://doi.org/10.1532/LH96.10011