Relationships among consanguinity, family history, and the onset of type 1 diabetes in children from Saudi Arabia

Published:September 20, 2021DOI:https://doi.org/10.1016/j.pcd.2021.09.002

      Highlights

      • Parental consanguinity may play a role in the development of T1DM.
      • Parental consanguinity was not clearly linked to T1DM in children.
      • A family history of autoimmunity was not clearly linked to T1DM in children.
      • A history of affected first-cousin parents increases the risk of T1DM.

      Abstract

      Aims

      We aimed to demonstrate the relationship between parental consanguinity and positive family histories of type 1 diabetes mellitus (T1DM) and autoimmune disease and the development of T1DM among children in Saudi Arabia.

      Methods

      This was a cross-sectional case-control study. In total, 192 patients and 188 healthy controls were enrolled from the Pediatric Diabetes Clinic at King Salman Military Hospital between January 2000 and December 2010. Detailed patients’ data recorded while distributing questionnaires to control samples included various gradations of consanguinity and family histories of T1DM and autoimmune disease.

      Results

      Parental consanguinity was not significantly associated with T1DM; however, children of first-cousin parents showed a higher risk of developing T1DM than did children of second-cousin parents. The presence of a family history of T1DM significantly differed between those with and without T1DM (p < 0.05). No association was observed between a family history of autoimmune disorders and the development of T1DM.

      Conclusions

      Parental consanguinity and family history of autoimmunity were not clearly linked to T1DM development in children, indicating that T1DM is a multifactorial disease. A history of affected first-cousin parents increases the risk of T1DM.

      Abbreviations:

      T1DM (Type 1 diabetes), HLA (human leukocyte antigen)

      Keywords

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      References

        • Remein Q.R.
        A current estimate of prevalence of diabetes mellitus in the United States.
        Ann. N. Y. Acad. Sci. 1999; 82: 229-235
        • Bacchus R.A.
        • Bell J.L.
        • Madkour M.
        • Kilshaw B.
        The prevalence of diabetes mellitus in male Saudi Arabs.
        Diabetologia. 1982; 23: 330-332
        • Fatani H.H.
        • Mira S.A.
        • el-Zubier A.G.
        Prevalence of diabetes mellitus in rural Saudi Arabia.
        Diabetes Care. 1987; 10: 180-183
        • Anokute C.C.
        Epidemiologic studies of diabetes mellitus in Saudi Arabia – Part I – screening of 3,158 males in King Saud University.
        J. R. Soc. Health. 1990; 110: 201-203
        • Al-Nozha M.M.
        • Al-Maatouq M.A.
        • Al-Mazrou Y.Y.
        • et al.
        Diabetes mellitus in Saudi Arabia.
        Saudi Med. J. 2004; 25: 1603-1610
        • Alqurashi K.A.
        • Aljabri K.S.
        • Bokhari S.A.
        Prevalence of diabetes mellitus in a Saudi community.
        Ann. Saudi Med. 2011; 31: 19-23
        • El Mouzan M.I.
        • Al Salloum A.A.
        • Al Herbish A.S.
        • et al.
        Consan guinity and major genetic disorders in Saudi children: a community-based cross-sectional study.
        Ann. Saudi Med. 2008; 28: 169-173
        • Zayeda H.
        • Ouhtitb A.
        • El Bekayc R.
        An Arab registry for type 1 diabetes: global benefits for type 1 diabetes patients.
        Curr. Med. Res. Opin. 2016; 32: 1681-1684
        • Albishi L.
        • Altoonisi M.
        • Alblewi S.
        • et al.
        Clinical demographic patterns of type 1 diabetes in Saudi children in Tabuk City, 2000-2010.
        J. Diabetes Mellitus. 2017; 7: 41-54
        • Hassan F.M.
        • Khatab A.A.
        • El-Fotoh W.M.
        • Ganh I.N.
        Prevalence of diabetes mellitus among school-age children.
        Menoufia Med. J. 2019; 32: 305-310
        • Stipancic G.
        • Sabolic L.L.G.
        • Malenica M.
        • et al.
        Incidence and trends of childhood type 1 diabetes in Croatia from 1995 to 2003.
        Diabetes Res. Clin. Pract. 2008; 80: 122-127
        • Haynes A.
        • Bower C.
        • Bulsara M.K.
        • et al.
        Continued increase in the incidence of childhood type 1 diabetes in a population-based Australian sample (1985–2002).
        Diabetologia. 2004; 47: 866-870
        • Casu A.
        • Pascutto C.
        • Bernardinelli L.
        • Songini M.
        Type 1 diabetes among Sardinian children is increasing: the Sardinian diabetes register for children aged 0–14 years (1989–1999).
        Diabetes Care. 2004; 27: 1623-1629
        • Ionescu-Tîrgovişte C.
        • Guja C.
        • Călin A.
        • Mota M.
        An increasing trend in the incidence of type 1 diabetes mellitus in children aged 0–14 years in Romania – ten years (1988–1997) EURODIAB study experience.
        J. Pediatr. Endocrinol. Metab. 2004; 17: 983-991
        • Karvonen M.
        • Viik-Kajander M.
        • Moltchanova E.
        • et al.
        Incidence of type I diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group.
        Diabetes Care. 2000; 23: 1516-1526
        • Maahs D.M.
        • West N.A.
        • Lawrence J.M.
        • Mayer-Davis E.J.
        Epidemiology of type 1 diabetes.
        Endocrinol. Metab. Clin. North Am. 2010; 39: 481-497
        • Alotaibia A.
        • Perry L.
        • Gholizadehb L.
        • Al-Ganmib A.
        Incidence and prevalence rates of diabetes mellitus in Saudi Arabia: an overview.
        J. Epidemiol. Glob. Health. 2017; 7: 211-218
        • El Mouzan M.I.
        • Al Salloum A.A.
        • Al Herbish A.S.
        • et al.
        Consanguinity and major genetic disorders in Saudi children: a community-based-cross-sectional study.
        Ann. Saudi Med. 2008; 28: 169-173
        • Parkkola A.
        • Härkönen T.
        • Ryhänen S.
        • et al.
        Finnish Pediatric Diabetes Register. Extended family history of autoimmune diseases and phenotype and genotype of children with newly diagnosed type 1 diabetes.
        Eur. J. Endocrinol. 2013; 169: 171-178
        • Salem M.A.
        • Tantawy A.A.
        • Radwan M.
        • et al.
        Clinico-epidemiological study of type 1 diabetes mellitus in Egyptian children and adolescents.
        Pediatr. Diabetes. 2010; 11: 94-95
        • Kakleas K.
        • Kandyla B.
        • Karayianni C.
        • Karavanaki K.
        Psychosocial problems in adolescents with type 1 diabetes mellitus.
        Diabetes Metab. 2009; 35: 339-350
        • Pérez F.
        • Santos J.L.
        • Calvillán M.
        • Carrasco E.
        HLA haplotypes in families with type 1 diabetes.
        Rev. Med. Chil. 1998; 126: 1455-1463
        • Kulmala P.
        • Savola K.
        • Petersen J.S.
        • et al.
        Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group.
        J. Clin. Invest. 1998; 101: 327-336
        • Vehik K.
        • Beam C.A.
        • Mahon J.L.
        • et al.
        Development of autoantibodies in the Trial Net Natural History Study.
        Diabetes Care. 2011; 34: 1897-1901
        • Achenbach P.
        • Bonifacio E.
        • Koczwara K.
        • Ziegler A.G.
        Natural history of type 1 diabetes.
        Diabetes. 2005; 54: S25-S31