Long-term cardiometabolic consequences among adolescent offspring born to women with type1 diabetes

Published:December 03, 2021DOI:https://doi.org/10.1016/j.pcd.2021.11.008


      • Adolescent born to diabetic women are at risk of developing metabolic syndromes.
      • Obesity, hypertension and dyslipidemia are the major risks factors.
      • The risk of obesity and hypertension are more prevalent in females than males.



      The aim of this study was to compare cardiometabolic measures between adolescents born to women with and without type1diabetes.


      In this cross-sectional study, 103 adolescents (51 males) aged 14−19 years, born to women with type1diabetes were enrolled in the study. Body mass index, blood pressure, urine microalbumin to creatinine ratio, hemoglobin A1c, serum urate, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, and estimated glomerular filtration rate (eGFR) were measured in all. The results were compared with 98 adolescents born to non-diabetic women.


      In multiple linear regression models, adolescent offspring of women with type 1 diabetes had significantly higher blood pressure (Odds ratio [OR] 2·45; 95% Confidence interval [CI] 2.1–2.8, hypertension (OR 2.52; 95% CI 1.99–3.01), body mass index (OR 2.22; 95% CI: 1.76–2.69), elevated total cholesterol (OR 1.5; 95% CI 0.2–2.9), low-density lipoprotein cholesterol (OR·33; 95% CI 1.06–1.64), triglyceride (OR 1.34; 95% CI: 1.05–1.70), eGFR (OR 0.96 ;95% CI 0.81–1.11) and microlabuminuria (OR 1.1; 95% CI: 0.87–1.12) compared to offspring of women without diabetes.


      The study demonstrates a strong correlation between maternal exposure to type1diabetes and higher risk of developing obesity, hypertension, dyslipidemia, eGFR, and microalbumiuria in the adolescent offspring.

      Graphical abstract


      eGFR (estimated glomerular filtration rate), TC (total cholesterol), LDLC (low density lipoprotein cholesterol), HDLC (high density lipoprotein cholesterol), TG (triglyceride)


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