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Distribution of lean mass and mortality risk in patients with type 2 diabetes

  • Author Footnotes
    1 These authors have contributed equally to this work and share first authorship.
    Li Ding
    Footnotes
    1 These authors have contributed equally to this work and share first authorship.
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Author Footnotes
    1 These authors have contributed equally to this work and share first authorship.
    Yuxin Fan
    Footnotes
    1 These authors have contributed equally to this work and share first authorship.
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China

    Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
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  • Author Footnotes
    1 These authors have contributed equally to this work and share first authorship.
    Jingting Qiao
    Footnotes
    1 These authors have contributed equally to this work and share first authorship.
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
    Search for articles by this author
  • Jing He
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Ruodan Wang
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Qing He
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Jingqiu Cui
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Zhongshu Ma
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Fangqiu Zheng
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Hua Gao
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Chenlin Dai
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Hongyan Wei
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Jun Li
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Yuming Cao
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
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  • Gang Hu
    Correspondence
    Corresponding author.
    Affiliations
    Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
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  • Ming Liu
    Correspondence
    Correspondence to: Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China.
    Affiliations
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China
    Search for articles by this author
  • Author Footnotes
    1 These authors have contributed equally to this work and share first authorship.
Published:October 19, 2022DOI:https://doi.org/10.1016/j.pcd.2022.09.003

      Highlights

      • Type 2 diabetes is associated with changes in distribution of muscle.
      • Central lean mass distribution is linked to risk of death in type 2 diabetes.
      • The association is independent of cardiovascular risk factors and leg lean mass.

      Abstract

      Aims

      The aim of the study is to evaluate the association of distribution of lean mass with the risk of all-cause mortality among patients with type 2 diabetes.

      Methods

      The present cohort study included 2 335 patients with type 2 diabetes. Lean mass was assessed by dual energy X-ray absorptiometry. Cox proportional hazards regressions were used to estimate the association of lean mass distribution on the risk of mortality.

      Results

      The average age of the patients was 58 years at baseline and 51.4% of patients were women. During a median follow-up of 4.31 years, 128 patients died. The multivariable-adjusted hazards ratios for all-cause mortality were 1.00, 1.63 (0.89–2.99), and 2.68(1.51–4.76) across the tertiles of android-to-gynoid lean mass ratio (P for trend < 0.001), respectively. The positive association of android-to-gynoid lean mass ratio with the risk of all-cause mortality was present among patients of different ages, body mass index ≥ 24 kg/m2, hemoglobin A1c ≥ 7.0%, nonsmokers, men, patients using insulin, and patients with diabetes durations of more than 10 years.

      Conclusions

      Higher android-to-gynoid lean mass ratio, assessed by dual energy X-ray absorptiometry, was significantly associated with increased risk of all-cause mortality among patients with type 2 diabetes.

      Keywords

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