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The impact of obesity epidemic on type 2 diabetes in children and adolescents: A systematic review and meta-analysis

  • Author Footnotes
    1 Qing-Xia He and Li Zhao have the same contribution.
    Qing-Xia He
    Footnotes
    1 Qing-Xia He and Li Zhao have the same contribution.
    Affiliations
    Hospital of Shimian County, Ya’an, China
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  • Author Footnotes
    1 Qing-Xia He and Li Zhao have the same contribution.
    Li Zhao
    Footnotes
    1 Qing-Xia He and Li Zhao have the same contribution.
    Affiliations
    Department of Clinical Epidemiology and Biostatistics, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing 400016, China
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  • Ji-Shuang Tong
    Affiliations
    Department of Clinical Epidemiology and Biostatistics, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing 400016, China
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  • Xiao-Yue Liang
    Affiliations
    Department of Clinical Epidemiology and Biostatistics, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing 400016, China

    Department of Humanities and Social Sciences, Daqing Campus of Harbin Medical University, Daqing 163319, Heilongjiang Province, China
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  • Ri-Na Li
    Affiliations
    Department of Clinical Epidemiology and Biostatistics, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing 400016, China
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  • Ping Zhang
    Affiliations
    Department of Clinical Epidemiology and Biostatistics, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing 400016, China
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  • Xiao-Hua Liang
    Correspondence
    Correspondence to: Clinical Epidemiology and Biostatistics Department, No.136 2nd Zhongshan Road, Chongqing 400014, China.
    Affiliations
    Department of Clinical Epidemiology and Biostatistics, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing 400016, China
    Search for articles by this author
  • Author Footnotes
    1 Qing-Xia He and Li Zhao have the same contribution.
Published:September 29, 2022DOI:https://doi.org/10.1016/j.pcd.2022.09.006

      Highlights

      • Obese increase the prevalence of T2D and prediabetes in children and adolescents.
      • The prevalence of T2D in obese children and adolescents was 13 times that in normal weight subjects.
      • The prevalence of prediabetes in obese subjects was 3 times that in normal subjects.
      • The values of insulin, HbA1c and HOMA-IR were greater in obese subjects than in normal weight subjects.

      Abstract

      Aim

      To assess the impact of the obesity epidemic on type 2 diabetes (T2D), prediabetes and glycometabolic indices in children and adolescents.

      Methods

      We searched four electronic databases (PubMed, Embase, Cochrane and Web of Science). Cross-sectional or cohort studies that reported on obesity and the prevalence of T2D or prediabetes in children and adolescents were reviewed. The study design, sample size and clinical outcomes were extracted from each study. The prevalence of T2D and prediabetes from the studies were pooled using meta-analysis methods.

      Results

      Meta-analysis of 228184 participants showed that the prevalence of T2D was 1.3% (95% confidence interval (CI), 0.6–2.1%) in obese subjects, which was 13 times that in normal weight subjects (0.1%, 95% CI, 0.01–0.2%). The prevalence of prediabetes in obese subjects was 3 times that in normal subjects at 17.0% (13.0−22.0%) vs. 6.0% (0.01−11.0%). Moreover, BMI was positively correlated with the prevalence of T2D, prediabetes and glycometabolic indices in obese children and adolescents.

      Conclusion

      The pooled results confirm that obesity in children and adolescents leads to statistically significant increases in the prevalence of T2D and prediabetes and in glycometabolic indicator levels.

      Keywords

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