- •Obese increase the prevalence of T2D and prediabetes in children and adolescents.
- •The prevalence of T2D in obese children and adolescents was 13 times that in normal weight subjects.
- •The prevalence of prediabetes in obese subjects was 3 times that in normal subjects.
- •The values of insulin, HbA1c and HOMA-IR were greater in obese subjects than in normal weight subjects.
To assess the impact of the obesity epidemic on type 2 diabetes (T2D), prediabetes and glycometabolic indices in children and adolescents.
We searched four electronic databases (PubMed, Embase, Cochrane and Web of Science). Cross-sectional or cohort studies that reported on obesity and the prevalence of T2D or prediabetes in children and adolescents were reviewed. The study design, sample size and clinical outcomes were extracted from each study. The prevalence of T2D and prediabetes from the studies were pooled using meta-analysis methods.
Meta-analysis of 228184 participants showed that the prevalence of T2D was 1.3% (95% confidence interval (CI), 0.6–2.1%) in obese subjects, which was 13 times that in normal weight subjects (0.1%, 95% CI, 0.01–0.2%). The prevalence of prediabetes in obese subjects was 3 times that in normal subjects at 17.0% (13.0−22.0%) vs. 6.0% (0.01−11.0%). Moreover, BMI was positively correlated with the prevalence of T2D, prediabetes and glycometabolic indices in obese children and adolescents.
The pooled results confirm that obesity in children and adolescents leads to statistically significant increases in the prevalence of T2D and prediabetes and in glycometabolic indicator levels.
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Published online: September 29, 2022
Accepted: September 16, 2022
Received in revised form: August 15, 2022
Received: April 11, 2022
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