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Ethnic differences between Asians and non-Asians in clustering-based phenotype classification of adult-onset diabetes mellitus: A systematic narrative review

  • Jithin Sam Varghese
    Correspondence
    Correspondence to: Hubert Department of Global Health, Rollins School of Public Health, and Emory Global Diabetes Research Center, Emory University, Atlanta, GA, 30322, USA.
    Affiliations
    Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA

    Emory Global Diabetes Research Center of Emory University and Woodruff Health Sciences Center, Atlanta, USA
    Search for articles by this author
  • K.M. Venkat Narayan
    Affiliations
    Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA

    Emory Global Diabetes Research Center of Emory University and Woodruff Health Sciences Center, Atlanta, USA
    Search for articles by this author
Published:September 22, 2022DOI:https://doi.org/10.1016/j.pcd.2022.09.007

      Highlights

      • There has not been a systematic examination of variation in phenotypical clusters by ethnicity.
      • Insulin deficiency cluster was more frequent than insulin resistant cluster among Asians.
      • Clusters with combined insulin deficiency and resistance were reported in Indian and Chinese populations.
      • Clusters have earlier age at diagnosis, lower BMI and poorer beta cell function among Asians, relative to Non-Asians.

      Abstract

      Several international studies have stratified people with diabetes into phenotypical clusters. However, there has not been a systematic examination of the variation in these clusters across ethnic groups. For example, some clusters appear more frequent among Asians and may have lower weight, age at diagnosis and poorer beta cell function.

      Abbreviations:

      BMI (Body mass index), HbA1c (Hemoglobin A1c), HOMA (Homeostatic Model Assessment), SAID (Severe Autoimmune Diabetes), SIDD (Severe Insulin-deficient Diabetes), SIRD (Severe Insulin-resistant Diabetes), MARD (Mild Age-related Diabetes), MOD (Mild Obesity Diabetes)

      Keywords

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