Highlights
- •The prevalence of neuropathic pain was approximately four times higher in patients with prediabetes than in controls.
- •Neuropathic pain rate was found to be 13.4% and 7% by using DN4 and LANSS questionnaires.
- •Higher HbA1c levels were associated with higher pain intensity scores.
- •The female gender was more associated with higher pain scores than the males.
Abstract
Aims
Neuropathic pain is associated with several clinical conditions, including anxiety,
depression, sleep disorders, and decreased quality of life; however, less evaluated
in prediabetes. This study aims to assess neuropathic pain through validated diagnostic
tools in prediabetes.
Methods
One hundred and seventy-two patients with prediabetes and 170 controls were included
in this cross-sectional study. The Leeds Assessment of Neuropathic Symptoms and Signs
(LANSS) Pain Scale and Douleur Neuropathique 4 Questions (DN4) were used to evaluate
neuropathic pain. The Visual Analog Scale (VAS) was used to estimate pain intensity.
Results
Twenty-three (13.4%) and 12 (7%) patients with prediabetes were diagnosed with neuropathic
pain using DN4 and LANSS questionnaires, respectively. Neuropathic pain rates of the
patients were higher than controls with two pain scales (p < 0.001). VAS scores were higher in prediabetes group than in controls (p = 0.021). LANSS, DN4, and VAS scores were positively correlated with HbA1c level
(r = 0.184, p = 0.016; r = 0.180, p = 0.018; r = 0.188, p = 0.014, respectively). LANNS and DN4 scores were higher in female patients than
in males (p < 0.001).
Conclusions
Neuropathic pain was increased in prediabetes by DN4 and LANNS questionnaires. An
appropriate diagnosis of neuropathic pain in prediabetes may prevent patients from
different pain-related clinical conditions.
Keywords
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Article info
Publication history
Published online: November 23, 2022
Accepted:
November 7,
2022
Received in revised form:
October 1,
2022
Received:
August 13,
2022
Identification
Copyright
© 2022 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
