Research Article| Volume 17, ISSUE 1, P33-37, February 2023

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The assessment of neuropathic pain in patients with prediabetes

  • Author Footnotes
    1 ORCID ID:
    Sema Hepşen
    Correspondence to: University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Department of Endocrinology and Metabolism, Sehit Omer Halisdemir Street, 06010 Ankara, Turkey.
    1 ORCID ID:
    University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey
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  • Dilek Baday Keskin
    Kirikkale University Medical Faculty, Department of Physical Medicine and Rehabilitation, Kirikkale, Turkey
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  • Erman Çakal
    University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey
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  • Author Footnotes
    1 ORCID ID:
Published:November 23, 2022DOI:


      • The prevalence of neuropathic pain was approximately four times higher in patients with prediabetes than in controls.
      • Neuropathic pain rate was found to be 13.4% and 7% by using DN4 and LANSS questionnaires.
      • Higher HbA1c levels were associated with higher pain intensity scores.
      • The female gender was more associated with higher pain scores than the males.



      Neuropathic pain is associated with several clinical conditions, including anxiety, depression, sleep disorders, and decreased quality of life; however, less evaluated in prediabetes. This study aims to assess neuropathic pain through validated diagnostic tools in prediabetes.


      One hundred and seventy-two patients with prediabetes and 170 controls were included in this cross-sectional study. The Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) Pain Scale and Douleur Neuropathique 4 Questions (DN4) were used to evaluate neuropathic pain. The Visual Analog Scale (VAS) was used to estimate pain intensity.


      Twenty-three (13.4%) and 12 (7%) patients with prediabetes were diagnosed with neuropathic pain using DN4 and LANSS questionnaires, respectively. Neuropathic pain rates of the patients were higher than controls with two pain scales (p < 0.001). VAS scores were higher in prediabetes group than in controls (p = 0.021). LANSS, DN4, and VAS scores were positively correlated with HbA1c level (r = 0.184, p = 0.016; r = 0.180, p = 0.018; r = 0.188, p = 0.014, respectively). LANNS and DN4 scores were higher in female patients than in males (p < 0.001).


      Neuropathic pain was increased in prediabetes by DN4 and LANNS questionnaires. An appropriate diagnosis of neuropathic pain in prediabetes may prevent patients from different pain-related clinical conditions.


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