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The relationship between hyperuricemia and anemia and metabolic syndrome in Korean adults: The Korea National Health and Nutrition Examination Survey 2019

  • Ha Young Seo
    Affiliations
    Department of Biomedical Laboratory Science, Wonkwang Health Science University, 345-13, Sinyong-dong, Iksan-si, Jeollabuk-do 54538, South Korea
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  • Chae Young Mun
    Affiliations
    Department of Biomedical Laboratory Science, Wonkwang Health Science University, 345-13, Sinyong-dong, Iksan-si, Jeollabuk-do 54538, South Korea
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  • Chea Yeon Park
    Affiliations
    Department of Biomedical Laboratory Science, Wonkwang Health Science University, 345-13, Sinyong-dong, Iksan-si, Jeollabuk-do 54538, South Korea
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  • Soo Bin Choi
    Affiliations
    Department of Biomedical Laboratory Science, Wonkwang Health Science University, 345-13, Sinyong-dong, Iksan-si, Jeollabuk-do 54538, South Korea
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  • Ji Hye Hwang
    Affiliations
    Department of Biomedical Laboratory Science, Wonkwang Health Science University, 345-13, Sinyong-dong, Iksan-si, Jeollabuk-do 54538, South Korea
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  • Jun Ho Lee
    Affiliations
    Department of Biomedical Laboratory Science, Wonkwang Health Science University, 345-13, Sinyong-dong, Iksan-si, Jeollabuk-do 54538, South Korea
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  • Hyun Yoon
    Correspondence
    Correspondence to: Department of Clinical Laboratory Science, Wonkwang Health Science University, 514, Iksan-daero, Iksan-si, Jeollabuk-do, 54538, South Korea.
    Affiliations
    Department of Biomedical Laboratory Science, Wonkwang Health Science University, 345-13, Sinyong-dong, Iksan-si, Jeollabuk-do 54538, South Korea
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Published:November 28, 2022DOI:https://doi.org/10.1016/j.pcd.2022.11.007

      Highlights

      • Hyperuricemia was not associated with anemia in overall population.
      • In non-metabolic syndrome (MetS) group, hyperuricemia was inversely associated with anemia.
      • In MetS group, hyperuricemia was positively associated with anemia.

      Abstract

      Aim

      The present study was conducted to assess the relationship between hyperuricemia and anemia in Korean adults with or without metabolic syndrome (MetS).

      Methods

      Data from 6073 adults (age ≥ 20 years) in the Eighth Korean National Health and Nutrition Examination Survey (2019) were analyzed.

      Results

      Several key findings were identified. First, after adjusting for the related variables, the hemoglobin [Hb] level in the hyperuricemia subgroup (uric acid [UA] ≥ 7.0 mg/dL in men or ≥ 6.0 mg/dL in women) was higher than in the normouricemia subgroup (UA < 7.0 mg/dL in men or < 6.0 mg/dL in women) in subjects with non-MetS (p = 0.005), whereas it was lower than in the normouricemia subgroup in subjects with MetS (p = 0.032). Second, after adjusting for the related variables, the odds ratio (OR) of anemia (Hb < 13.0 g/dL in men or < 12 g/dL in women), using the normouricemia subgroup as a reference, was negatively significant for the hyperuricemia subgroup in subjects with non-MetS (OR, 0.478; 95 % CI, 0.300–0.761) but positively significant for the hyperuricemia subgroup in subjects with MetS (OR, 1.765; 95 % CI, 1.160–2.198).

      Conclusions

      Hyperuricemia was associated with a decrease in anemia in non-MetS but an increase in anemia in MetS.

      Keywords

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