Highlights
- •Retrospective cohort study of diabetes patients who underwent cataract surgery.
- •Probed association of glycemic control and pseudophakic cystoid macular edema-CME.
- •Main variables influencing risk for CME were diabetic retinopathy and HbA1c level.
- •High glycated hemoglobin level was independent risk factor for developing CME.
- •CME patients likelier younger, longer diabetes, type 1 diabetes, and retinopathic.
Abstract
Aims
Cataract, the most common cause of blindness, has higher prevalence among patients
with diabetes mellitus. About 20% of cataract surgeries are performed on patients
with diabetes. One of the complications of cataract surgery is pseudophakic cystoid
macular edema (CME). This study examined whether patients’ glycemic control (as indicated
by HbA1c level before cataract surgery) is associated with CME incidence within one
year post-surgery.
Methods
We conducted a retrospective cohort study of 1285 diabetes patients over age 18 who
underwent cataract surgery between January 2015 and January 2020. Data were obtained
from medical records reporting glycated hemoglobin (HbA1c) level prior to surgery
and post-operative CME with intraocular anti-vascular endothelial growth factor injections.
Results
The patients with CME complications were younger, with longer duration diabetes, and
higher percentages of type 1 diabetes and diabetic retinopathy. The main variables
influencing risk of post-operative CME were found to be diabetic retinopathy and HbA1c
level. Multivariate analysis revealed that HbA1c is an independent risk for post-operative
CME with a relative risk of 2.01 when HBa1c is above 7 c (95% CI, 1.10–3.67).
Conclusion
The study demonstrates that pre-cataract surgery diabetes control, measured by HbA1c
level, is an independent risk factor for developing post-surgery CME.
Keywords
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Article info
Publication history
Published online: January 02, 2023
Accepted:
December 21,
2022
Received in revised form:
November 12,
2022
Received:
July 30,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
