Highlights
- •Among Chinese women with gestational diabetes mellitus, we found:
- •Maternal prepregnancy obesity predicted offspring overweight before 2 years of age.
- •Paternal prepregnancy obesity predicted offspring overweight before 2 years of age.
- •Maternal and paternal obesity had an additive effect on the offspring overweight.
- •Risk of overweight increased with age in the offspring of parents with obesity.
Abstract
Aims
To examine the associations of parental obesity prior to pregnancy with offspring
overweight before two years of age among children of Chinese women with gestational
diabetes mellitus (GDM).
Methods
Offspring of women with GDM (n = 774) who were diagnosed in 2010–2012 were followed
up to two years of age in Tianjin, China. Multinomial logistic regression was used
to obtain odds ratios (ORs) and 95% confidence interval (CI) of maternal and paternal
prepregnancy obesity with offspring overweight at < 1, 1–1.5, and 1.5–2 years of age.
Results
Among 774 offspring of women with GDM, 457 (59.0%) of the offspring developed overweight
before two years of age. Maternal prepregnancy obesity was associated with increased
risk of offspring overweight at 1–1.5 years of age and 1.5–2 years of age (ORs: 1.98,
95%CI: 1.09–3.59 & 2.14, 1.10–4.15, respectively). Paternal prepregnancy obesity was
only associated with elevated risk of offspring overweight at 1.5–2 years of age (1.82,
1.08–3.06). Furthermore, copresence of both maternal and paternal obesity prior to
pregnancy had an additive effect on the risk of offspring overweight at 1.5–2 years
of age (3.73, 1.50–9.27).
Conclusions
Parental prepregnancy obesity predicted offspring overweight before two years of age
among children of Chinese women with GDM.
Abbreviations:
GDM (Gestational diabetes mellitus), RCT (Randomized controlled trial), GCT (Glucose challenge test), OGTT (Oral glucose tolerance test), PG (Plasma glucose), IC (Intensive care), UC (Usual care), SMBG (Self-monitoring of blood glucose), SBP (Systolic blood pressure), DBP (Diastolic blood pressure), BMI (Body mass index), WHO (World Health Organization), SD (Standard deviation), IQR (Interquartile range), OR (Odds ratio), CI (Confidence interval)Keywords
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Article info
Publication history
Published online: December 30, 2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
