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Parental prepregnancy obesity and offspring overweight before two years of age among Chinese women with gestational diabetes

  • Author Footnotes
    1 The authors contributed equally to this manuscript.
    ,
    Author Footnotes
    2 Orcid ID:0000–0001-8795–3864
    Ming Gao
    Footnotes
    1 The authors contributed equally to this manuscript.
    2 Orcid ID:0000–0001-8795–3864
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China
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  • Author Footnotes
    1 The authors contributed equally to this manuscript.
    ,
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    3 Orcid ID:0000–0003-2902–5570
    Hui Wang
    Footnotes
    1 The authors contributed equally to this manuscript.
    3 Orcid ID:0000–0003-2902–5570
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China
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  • Author Footnotes
    4 Orcid ID:0000–0001-5011–7985
    Weiqin Li
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    4 Orcid ID:0000–0001-5011–7985
    Affiliations
    Project Office, Tianjin Women and Children’s Health Centre, Tianjin, China
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  • Author Footnotes
    5 Orcid ID:0000–0003-1958–810X
    Ping Shao
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    5 Orcid ID:0000–0003-1958–810X
    Affiliations
    Project Office, Tianjin Women and Children’s Health Centre, Tianjin, China
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  • Author Footnotes
    6 Orcid ID:0000–0002-6036–3220
    Ninghua Li
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    6 Orcid ID:0000–0002-6036–3220
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China
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  • Author Footnotes
    7 Orcid ID: 0000–0002-6142–6326
    Jinnan Liu
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    7 Orcid ID: 0000–0002-6142–6326
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China
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  • Author Footnotes
    8 Orcid ID: 0000–0003-0422–9841
    Peng Wang
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    8 Orcid ID: 0000–0003-0422–9841
    Affiliations
    Project Office, Tianjin Women and Children’s Health Centre, Tianjin, China
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  • Author Footnotes
    9 Orcid ID:0000–0003-2260–6997
    Shuang Zhang
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    9 Orcid ID:0000–0003-2260–6997
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    Project Office, Tianjin Women and Children’s Health Centre, Tianjin, China
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    6 Orcid ID:0000–0002-6036–3220
    ,
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    10 Orcid ID:0000–0003-2777–2572
    Jing Li
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    6 Orcid ID:0000–0002-6036–3220
    10 Orcid ID:0000–0003-2777–2572
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China

    Tianjin Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, China

    Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, China
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    11 Orcid ID: 0000–0002-4901–3545
    Zhijie Yu
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    11 Orcid ID: 0000–0002-4901–3545
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    Population Cancer Research Program, Dalhousie University, Halifax, NS, Canada
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    12 Orcid ID:0000–0002-6172–8017
    Gang Hu
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    12 Orcid ID:0000–0002-6172–8017
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    Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
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  • Author Footnotes
    13 Orcid ID:0000–0002-6742–0830
    Junhong Leng
    Correspondence
    Corresponding author.
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    13 Orcid ID:0000–0002-6742–0830
    Affiliations
    Project Office, Tianjin Women and Children’s Health Centre, Tianjin, China
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  • Author Footnotes
    14 Orcid ID:0000–0002-9462–7992
    Xilin Yang
    Correspondence
    Corresponding author at: Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
    Footnotes
    14 Orcid ID:0000–0002-9462–7992
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China

    Tianjin Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, China

    Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, China
    Search for articles by this author
  • Author Footnotes
    1 The authors contributed equally to this manuscript.
    2 Orcid ID:0000–0001-8795–3864
    3 Orcid ID:0000–0003-2902–5570
    4 Orcid ID:0000–0001-5011–7985
    5 Orcid ID:0000–0003-1958–810X
    6 Orcid ID:0000–0002-6036–3220
    7 Orcid ID: 0000–0002-6142–6326
    8 Orcid ID: 0000–0003-0422–9841
    9 Orcid ID:0000–0003-2260–6997
    10 Orcid ID:0000–0003-2777–2572
    11 Orcid ID: 0000–0002-4901–3545
    12 Orcid ID:0000–0002-6172–8017
    13 Orcid ID:0000–0002-6742–0830
    14 Orcid ID:0000–0002-9462–7992
Published:December 30, 2022DOI:https://doi.org/10.1016/j.pcd.2022.12.005

      Highlights

      • Among Chinese women with gestational diabetes mellitus, we found:
      • Maternal prepregnancy obesity predicted offspring overweight before 2 years of age.
      • Paternal prepregnancy obesity predicted offspring overweight before 2 years of age.
      • Maternal and paternal obesity had an additive effect on the offspring overweight.
      • Risk of overweight increased with age in the offspring of parents with obesity.

      Abstract

      Aims

      To examine the associations of parental obesity prior to pregnancy with offspring overweight before two years of age among children of Chinese women with gestational diabetes mellitus (GDM).

      Methods

      Offspring of women with GDM (n = 774) who were diagnosed in 2010–2012 were followed up to two years of age in Tianjin, China. Multinomial logistic regression was used to obtain odds ratios (ORs) and 95% confidence interval (CI) of maternal and paternal prepregnancy obesity with offspring overweight at < 1, 1–1.5, and 1.5–2 years of age.

      Results

      Among 774 offspring of women with GDM, 457 (59.0%) of the offspring developed overweight before two years of age. Maternal prepregnancy obesity was associated with increased risk of offspring overweight at 1–1.5 years of age and 1.5–2 years of age (ORs: 1.98, 95%CI: 1.09–3.59 & 2.14, 1.10–4.15, respectively). Paternal prepregnancy obesity was only associated with elevated risk of offspring overweight at 1.5–2 years of age (1.82, 1.08–3.06). Furthermore, copresence of both maternal and paternal obesity prior to pregnancy had an additive effect on the risk of offspring overweight at 1.5–2 years of age (3.73, 1.50–9.27).

      Conclusions

      Parental prepregnancy obesity predicted offspring overweight before two years of age among children of Chinese women with GDM.

      Abbreviations:

      GDM (Gestational diabetes mellitus), RCT (Randomized controlled trial), GCT (Glucose challenge test), OGTT (Oral glucose tolerance test), PG (Plasma glucose), IC (Intensive care), UC (Usual care), SMBG (Self-monitoring of blood glucose), SBP (Systolic blood pressure), DBP (Diastolic blood pressure), BMI (Body mass index), WHO (World Health Organization), SD (Standard deviation), IQR (Interquartile range), OR (Odds ratio), CI (Confidence interval)

      Keywords

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