Highlights
- •The 10-year CVD risk was reduced by 0.96% with a d‐DPP at 4 months.
- •The proportion of people with cardiometabolic risk factors was reduced in a d‐DPP.
- •Targeting peoples with prediabetes at intermediate or high ASCVD risk at baseline.
Abstract
Objective
To examine changes in cardiovascular disease (CVD) risk outcomes of overweight/obese
adults with prediabetes.
Methods
Using data from a randomized control trial of digital diabetes prevention program
(d‐DPP) with 599 participants. We applied the atherosclerotic CVD (ASCVD) risk calculator
to predict 10-year CVD risk for d‐DPP and small education (comparison) groups. Between-group
risk changes at 4 and 12 months were compared using a repeated measures linear mixed-effect
model. We examined within-group differences in proportion of participants over time
for specific CVD risk factors using generalized estimating equations.
Results
We found no differences between baseline 10-year ASCVD risk. Relative to the comparison
group, the d‐DPP group experienced greater reductions in predicted 10-year ASCVD risk
at each follow-up visit and a significant group difference at 4 months (−0.96%; 95%
confidence interval: −1.58%, −0.34%) (but not at 12 months). Additionally, we observed
that the d‐DPP group experienced a decreased proportion of individuals with hyperlipidemia
(18% and 16% from baseline to 4 and 12 months), high-risk total cholesterol (8% from
baseline to 12 months), and being insufficiently active (26% and 22% from baseline
to 4 and 12 months at follow-up time points.
Conclusions
Our findings suggest that a digitally adapted DPP may promote the prevention of cardiometabolic
disease among overweight/obese individuals with prediabetes. However, given the lack
of maintenance of effect on ASCVD risk at 12 months, there may also be a need for
additional interventions to sustain the effect detected at 4 months.
Keywords
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Article info
Publication history
Published online: January 23, 2023
Accepted:
January 16,
2023
Received in revised form:
January 2,
2023
Received:
June 16,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
