Highlights
- •Imbalances in the gut microbiota may lead to the development and progression of diabetes.
- •Sleep disorders are very prevalent in individuals with diabetes and can be related to a worse prognosis for this disease.
- •Probiotics have been linked to improvements in sleep and glucose and high density lipoprotein cholesterol levels.
- •Probiotic supplementation may be considered to control diabetes, enhance metabolic regulation and sleep quality.
Abstract
In this manuscript, we call attention to the importance of investigating affordable
strategies to improve the management of diabetes. Studies indicate that imbalances
in the gut microbiota may lead to the development and progression of this disease.
At the same time, poor sleep and sleep disorders, which are very prevalent in individuals
with diabetes, can be related to a worse prognosis for the disease and can be impacted
by changes in the intestinal microbiome. A suggested treatment that may be effective
in controlling diabetes and improving sleep quality through increased metabolic regulation
is probiotic supplementation. Scientific evidence has shown a relationship between
the use of probiotics and improvements in sleep, in glucose concentrations, and in
the levels of high density lipoprotein cholesterol. We suggest that probiotic supplementation
can play an important role in the management of diabetes and sleep disorders in diabetic
patients. Further randomized clinical studies should be undertaken to better understand
the impact and effectiveness of the use of probiotics in improving sleep and controlling
diabetes.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Primary Care DiabetesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- WHO Global report on diabetes: a summary.Int. J. Noncommun. Dis. 2016; 1: 3-8
World Health Organization, Assessing National Capacity for the Prevention and Control of Noncommunicable Diseases: Report of the 2019 Global Survey, 2020.
- The epidemiology of sleep and diabetes.Curr. Diabetes Rep. 2018; 18: 82
- The reciprocal interaction between sleep and type 2 diabetes mellitus: facts and perspectives.Braz. J. Med. Biol. Res. 2008; 41: 180-187
- Sleep duration and risk of type 2 diabetes: a meta-analysis of prospective studies.Diabetes Care. 2015; 38: 529-537
- From role of gut microbiota to microbial-based therapies in type 2-diabetes.Infect. Genet. Evol. 2020; 104268
- Beyond gut microbiota: understanding obesity and type 2 diabetes.Hormones. 2015; 14: 358-369
- Characterization of the gut microbiota of individuals at different T2D stages reveals a complex relationship with the host.Microorganisms. 2020; 8: 94
- The gut microbiome and the brain.J. Med. Food. 2014; 17: 1261-1272
- Chronic sleep disruption alters gut microbiota, induces systemic and adipose tissue inflammation and insulin resistance in mice.Sci. Rep. 2016; 6: 35405
- The effect of probiotic supplementation on glycemic control and lipid profile in patients with type 2 diabetes: a randomized placebo controlled trial.Diabetes Metab. Syndr. 2019; 13: 175-182
- Effects of probiotics on cognitive reactivity, mood, and sleep quality.Front. Psychiatry. 2019; 10
- Risk and safety of probiotics.Clin. Infect. Dis. 2015; 60: S129-S134
- Guidelines for the Evaluation of Probiotics in Food.FAO/WHO, London, ON2002
Article info
Publication history
Published online: February 11, 2023
Accepted:
January 31,
2023
Received:
March 11,
2022
Identification
Copyright
© 2023 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
