Research Article| Volume 17, ISSUE 3, P273-277, June 2023

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Inflammatory and metabolic markers and comorbidities remission following sleeve gastrectomy: A single center one-year cohort study

  • Author Footnotes
    1 These authors are equally corresponding authors.
    Author Footnotes
    2 0000-0003-3332-9382
    Zahra Davoudi
    Correspondence to: Department of Internal Medicine, Endocrinology clinic, Loghman Hakim Medical And Educational Center, Kamali Street, Southern Karegar Street, Tehran, Iran.
    1 These authors are equally corresponding authors.
    2 0000-0003-3332-9382
    Department of Internal Medicine, Endocrinology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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  • Author Footnotes
    3 0000-0002-5101-8417
    Sina Raissi Dehkordi
    3 0000-0002-5101-8417
    Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
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  • Author Footnotes
    4 0000-0002-0562-0941
    Shahriar Nikpour
    4 0000-0002-0562-0941
    Department of Internal Medicine, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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  • Masoud Shafiee
    Internal medicine assistant, school of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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  • Author Footnotes
    5 0000-0001-7586-4282
    Ali Mohammadian
    5 0000-0001-7586-4282
    School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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  • Author Footnotes
    6 0000-0002-4636-6572
    Yeganeh Farsi
    Correspondence to: School of Medicine, Koodakyar Street, Velenjak, Tehran, Iran.
    6 0000-0002-4636-6572
    School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Search for articles by this author
  • Author Footnotes
    1 These authors are equally corresponding authors.
    2 0000-0003-3332-9382
    3 0000-0002-5101-8417
    4 0000-0002-0562-0941
    5 0000-0001-7586-4282
    6 0000-0002-4636-6572
Published:March 07, 2023DOI:


      • Bariatric surgery is safe and effective in diabetic patients.
      • Every unit of increased BMI improves the chance of diabetes remission by 16%.
      • Increased levels of HbA1C reduce the chance of diabetes remission by 0.9%.
      • Laparoscopic sleeve gastrectomy improves commodities in diabetic patients.


      Background and aim

      Obesity is a global concern with several health-related complications. Bariatric surgeries are major treatment options in patients with obesity and other comorbidities. This study aims to investigate the effects of sleeve gastrectomy on metabolic indexes, hyperechogenic liver changes, inflammatory state, diabetes, and other obesity-related comorbidities remission after the sleeve gastrectomy.


      This prospective study was conducted on patients with obesity candidates for laparoscopic sleeve gastrectomy. Patients were followed for one year after the surgery. Comorbidities, metabolic and inflammatory parameters were assessed before and one- year after the surgery.


      137 patients (16 males, 44 in the DM group) underwent sleeve gastrectomy. One year after the study, obesity-related comorbidities improved significantly; diabetes had complete remission in 22.7% and partial remission in 63.6% of patients. Hyper-cholesterolemia, hyper-triglyceridemia, and hyper-uricemia also improved in 45.6%, 91.2%, and 69% of the patients. Metabolic syndrome indexes improved in 17.5% of the patients. Also, the prevalence of hyperechogenic changes in the liver has declined from 21% before the surgery to 1.5% after that. Based on logistic regression analysis, increased levels of HbA1C reduced the chance of diabetes remission by 0.9%. In comparison, every unit of increased BMI before the surgery improved the case of diabetes remission by 16%.


      Laparoscopic sleeve gastrectomy is a safe and effective treatment option in patients with obesity and diabetes. Laparoscopic sleeve gastrectomy alleviates BMI and insulin resistance and effectively improves other obesity-related comorbidities such as Hypercholesterolemia, hyper-triglyceridemia, hyper-uricemia, and hyperechogenic changes of the liver. HbA1C and BMI before the surgery are notable predictors of diabetes remission within the first year after the surgery.


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